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Better Trucks Adds 4.6 Million Households with New England Delivery Expansion

Better Trucks

Better Trucks, a technology-driven logistics firm focused on rapid parcel delivery, now delivers to millions of households in Boston and greater New England. Shippers are already utilizing this additional service area that is made possible through Better Trucks’ partnership with Optima Overnight. Better Trucks’ delivery area now reaches 139 million people and over 40% of U.S. households from coast to coast. “Our current clients as well as prospects have asked for service in New England, and our open technology platform made it easy to expand our partner network in time for peak season,” said Josh Fredman, Better Trucks Senior Vice President of Commercial and Growth. “Optima is a tech-forward carrier that shares our commitment to deliver on-time with full transparency to shippers and make their customers happy.” The partnership adds more than 1,000 new zip codes to Better Trucks’ footprint in Massachusetts, Connecticut, New Hampshire, and Rhode Island. “Boston is a key market where we now add more choices for shippers. Our current clients have expressed great interest in diversifying their carriers there,” added Fredman. “Our partnership with Better Trucks adds volume to densify our operations, and opens a path for our clients to expand to Better Trucks vast coverage across the country,” said Len Braudis, Optima Overnight, President. “The smooth tech integration allowed us to operationalize this partnership in record time.” The bilateral partnership allows Better Trucks’ clients to ship to New England with a seamless experience, utilizing a Better Trucks label with last-mile delivery fulfilled by Optima. Similarly, Optima clients have the same option with fulfillment by Better Trucks in its footprint. About Better Trucks Better Trucks is a technology-driven, last-mile delivery carrier built for digital commerce. Founded in 2019, it delivers a better experience for retailers, e-commerce firms, and fulfillment centers to ship parcels faster with better communication and better value. Specializing in next-day and two-day deliveries, Better Trucks sorts and labels packages within its strategically-placed warehouses and delivers them through its extensive driver network. Visit bettertrucks.com for more information. About Optima Overnight Optima specializes in serving direct-to-consumer, e-commerce businesses, along with medical and traditional courier clients by focusing on efficient last-mile delivery solutions. Through its robust logistical network, Optima provides scheduled route services for industries such as libraries and banks; and offers last-mile distribution for major brands. By leveraging advanced technology, Optima helps mid-sized to large shippers optimize their operations, improving transit times, reducing costs, and enhancing shipment visibility. Clients working with Optima benefit from accurate delivery information, real-time tracking, and transparent communication. Optima’s technology, powered by Beans.ai, ensures operational efficiency and reliable service. For businesses looking for cost-effective alternatives to traditional providers like UPS and FedEx, Optima offers a scalable solution that drives efficiency without compromising service quality. Contact Details For Better Trucks John Hall +1 303-223-6965 john@hallwaycommunications.com Company Website https://www.bettertrucks.com/

November 04, 2024 08:01 AM Central Standard Time

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Luxy Hair Launches in the U.S. Amazon Premium Beauty Store

Luxy Hair

Luxy Hair, the #1 leading clip-in hair extensions brand, is proud to announce its debut in the U.S. Amazon Premium Beauty Store. Luxy Hair, part of the Beauty Industry Group portfolio, is expanding its reach by providing easy access to its high-quality, ethically sourced products through one of the world’s largest e-commerce platforms. “We are thrilled to collaborate with Amazon to continue our mission of empowering women to feel confident in their own hair,” said Amy Sveda, President of Luxy Hair. “We are excited to bring our ethically sourced, premium-quality hair solutions to a larger audience, helping more women regain confidence and embrace their hair identity.” Amazon customers can now explore and shop Luxy Hair’s extensive shade range, including hair swatches for easy color-matching. Luxy Hair’s storefront will feature best-selling items including the Classic Clip-In Extensions, Seamless Clip-In Extensions, and Halo® Extensions; customer-loved accessories such as Signature Hair Curler, and TikTok favorite Luxy Hair x Acquired Style Collection; and the newer and fastest growing solutions-based products including Scalp Hair Fill-Ins and Thinning Hair Fill-Ins, directly in Amazon’s U.S. Premium Beauty Store. Since its inception in 2010, Luxy Hair has gained recognition for delivering natural-looking, premium quality, do-it-yourself hair extensions made from 100% ethically sourced Remy human hair. The brand is renowned for its dedication to exceptional customer service and its award-winning shade range that meets various hair needs—from adding instant volume and length to addressing hair thinning and loss. Luxy Hair sets itself apart through its exceptional craftsmanship, unwavering commitment to transparency, and dedication to sustainable practices. By fostering open dialogue about hair loss and challenging the stigma surrounding hair extensions, Luxy Hair creates an inclusive space where women feel empowered, supported, and confident throughout their unique hair journeys. For more information, please visit www.luxyhair.com or @luxyhair on social media. Explore the full range of products at www.amazon.com/luxyhair. About Luxy Hair: The #1 rated hair extensions brand in the world, Luxy Hair is on a mission to take the guesswork out of natural-looking beautiful hair. Made from 100% ethically sourced Remy human hair, Luxy Hair creates premium quality hair extensions for all of life’s moments. Having amassed over 250K customers in more than 165 countries, with a large loyal following, Luxy Hair is renowned for its exceptional customer service and engagement. Luxy Hair is the do-it-yourself solution for anyone, any day, anywhere. About Beauty Industry Group: BIG, established in 2004, is the global market leader for professionally installed hair extensions and related beauty products. BIG's professional products are sold in more than 1,300 stores throughout North America and its collective brands service more than 30,000 salons across 165 countries. BIG has offices in four countries and is headquartered in Salt Lake City, UT. Contact Details Six One Agency Camryn Carlson camryn@six-one.com Luxy Hair Gillian Fetters gillianf@luxyhair.com

October 30, 2024 08:03 AM Eastern Daylight Time

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HUSQVARNA® VIKING® Introduces Epic Quilt™ 97

SVP Worldwide

SVP Worldwide, the parent company of HUSQVARNA® VIKING®, a leader in the sewing industry, proudly announced today the launch of its latest innovation, the Epic Quilt™ 97, what quilt dreams are made of. The Epic Quilt™ 97 boasts a spacious workspace perfect for large projects, accommodating even king-sized quilts. With over 12" (310mm) to the right of the needle and a working area height exceeding 5.5" (140mm), it provides ample room for handling bulky materials. A particular standout feature of the Epic Quilt™ 97 is its sewing projection technology, allowing quilters to preview their stitches before sewing. Stitch preview ensures perfect placement every time. The adjustable lines, angles, and grids in sewing mode make aligning stitches effortless, saving valuable time while achieving precision. The Epic Quilt™ 97 also comes equipped with meticulously designed accessories that enhance creativity and ease of use. Included are advanced accessories providing quilters with the tools needed to elevate their craft to new heights including an Extension Table with Adjustable Guide, Rotating Self Healing Cutting Mat (12” x 12”), Rotary Cutting Tool + Replacement Blades, Ruler Set (6” x 12” and 6” x 6” sizes), Free Motion Ruler Foot, Quilt Binder, HUSQVARNA® VIKING® Universal Needles 80/12 5-Pack and the HUSQVARNA® VIKING® Quilting Needles Assorted Sizes 5-Pack. "We are excited to unveil the Epic 97Q, a groundbreaking advancement in our tradition of innovation,” stated Jason Zielke, chief product officer at SVP Worldwide. “Leveraging AI technology, the machine recommends the optimal sewing foot setup for each stitch, and the built-in projection system simplifies the process of creating complex stitches leading to exceptional precision and quality. We added to this machine a suite of the most important accessories that will advance the quilting experience. The Epic 97Q combines our rich heritage with cutting-edge technology, empowering you to create intricate, beautifully executed quilts with unparalleled ease and accuracy." The Epic Quilt 97 is now available online. For more information, please visit our website at www.husqvarnaviking.com. Media Assets About SVP Worldwide SVP Worldwide is the world’s largest consumer sewing machine company, accounting for approximately one out of every three sewing machines sold globally. The company’s iconic brands - SINGER®, VIKING®, PFAFF®, and mySewnet™, have collectively delighted consumers for over 170 years with a distinct heritage and global fanbase. These premium brands and products are regarded as the first-rate choice for a range of consumers from serious sewists to beginners in crafting. SVP Worldwide operates facilities around the globe that support designing, manufacturing, selling, and supplying the world’s most iconic sewing machine brands. Headquartered out of Nashville, TN (USA) with operations internationally, SVP Worldwide boasts regional headquarters, manufacturing facilities, and commercial offices across Europe, South America, Asia, and Australia. Combined, SVP reaches consumers in more than 180 countries on five continents. SVP brands and products are sold online at www.Singer.com and across a network of sewing machine dealers, mass, online, and specialty retailers, distributors, and through the company’s 130+ internally operated retail stores. In 2021, Platinum Equity acquired the controlling stake in SVP-Singer Holdings, Inc., and its wholly owned subsidiaries ("SVP Worldwide"). To learn more, visit www.svpworldwide.com. Contact Details Razor Sharp PR Ray Young +1 512-694-6097 ray@razorsharppr.com

October 10, 2024 10:00 AM Central Daylight Time

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NAVEX Unveils Curated AI Content Library to Simplify Compliance and Risk Mitigation

NAVEX Global

NAVEX, the global leader in integrated risk and compliance management software, introduces its new AI-focused content library designed to help organizations address the rapidly evolving landscape of Artificial Intelligence (AI) regulations and frameworks. As AI technologies become part of daily operations, many organizations find themselves entering uncharted waters regarding effective AI governance. According to Forrester’s September 2023 Artificial Intelligence Pulse Survey, 56% of AI decision-makers said their organization will use generative AI (genAI) in the next 12 months for internal or customer-facing production applications for employee productivity. The stakes are rising, and navigating these challenges without a clear framework can feel overwhelming, leaving companies vulnerable to risks. NAVEX plays a critical role by enabling companies to implement strong controls, automate workflows, and perform comprehensive testing. This approach simplifies complex challenges and transforms them into strategic opportunities. NAVEX’s content library is continuously curated to cover international and industry-specific AI regulations, including emerging standards and compliance requirements. By leveraging this resource, customers can ensure their AI initiatives align with ethical guidelines and regulatory mandates. A.G. Lambert, Chief Product Officer at NAVEX, captures the pivotal moment many organizations face: "As AI technologies revolutionize industries, companies find themselves standing at a crossroads, navigating the intricate landscape of effective AI governance. Our AI content not only empowers risk management professionals to establish crucial controls but also enhances efficiency by automating compliance processes. This dual approach enables organizations to embrace AI technology with confidence, transforming challenges into opportunities for growth and innovation." Key features of the NAVEX AI content library include: Centralized AI Regulatory Resources: Access a consolidated library of global AI regulations and industry-specific guidelines. Streamlined Control Development: Simplify the process of creating and implementing AI-specific controls to align with emerging regulations. Automated Compliance Monitoring: Leverage automation to track compliance requirements and ensure adherence through continuous control testing. Enhanced Risk Mitigation: Identify and mitigate AI-related risks proactively using structured regulatory frameworks. Future-Proof Compliance Strategy: Stay ahead of evolving AI laws and standards, ensuring the organization remains compliant and competitive. NAVEX is enhancing AI governance with its NAVEX One platform that streamlines the process of developing and distributing AI-related policies, ensuring companies stay aligned with fast-changing compliance requirements in the AI landscape. Should employees or third parties have AI-related issues or concerns, the NAVEX One platform offers employees a secure solution to report them. This proactive approach helps organizations identify and mitigate potential risks early on. The NAVEX content library offers over 400 regulations and compliance frameworks, continuously expanding to meet the demands of an evolving regulatory environment. This extensive resource includes critical AI regulations such as the EU AI Act, NIST AI Risk Management Framework, and the Colorado Artificial Intelligence Act. As AI governance becomes increasingly critical, NAVEX integrates AI training, incident management, and policy management into this comprehensive resource, ensuring organizations stay ahead of compliance requirements. With real-time updates, businesses can select tailored content to meet emerging AI regulatory standards, providing the tools to navigate current and future compliance challenges effectively. This seamless integration helps organizations maintain a proactive risk and compliance posture while leveraging cutting-edge technologies. The new AI content library is now available as part of NAVEX’s Integrated Risk Management solution. For more information, visit NAVEX’s Website. NAVEX is trusted by thousands of customers worldwide to help them achieve the business outcomes that matter most. As the global leader in integrated risk and compliance management software and services, we deliver solutions through the NAVEX One platform, the industry’s most comprehensive governance, risk and compliance (GRC) information system. For more information, visit NAVEX.com and our blog. Follow us on Twitter and LinkedIn. Contact Details Navex Global +1 617-388-5773 scott.levesque@navex.com Company Website https://navex.com

October 08, 2024 08:00 AM Eastern Daylight Time

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Market Alert: Silexion Therapeutics (NASDAQ: SLXN) Sees Record Volumes Following Breakthrough Preclinical Data for SIL-204

Global Markets News

Shares of Silexion Therapeutics (NASDAQ:SLXN) are seeing significatnly today after the company announced promising new preclinical data for its next-generation siRNA candidate, SIL-204. The stock saw a significant initial of price spike of over 50% in pre-market activity as investors responded to the latest developments in Silexion's RNA interference (RNAi) platform, which targets KRAS-driven cancers. As of now, volume is at record highs, currently standing at over 50 million shares today. The company revealed that SIL-204, an extended-release microparticle formulation, demonstrated substantial tumor reduction and necrosis in mouse models of pancreatic cancer bearing the KRAS G12D mutation—one of the most common mutations found in pancreatic cancer patients. This latest data builds on a string of recent successes for Silexion, including its September 24 announcement of results from the Phase 2 trial for its first-generation product, LODER™, which showed significant improvements in tumor resectability among non-resectable pancreatic cancer patients. Alongside the new preclinical results, Silexion has recently reported plans to begin toxicology studies for SIL-204 in preparation for Phase 2/3 clinical trials expected to commence in the first half of 2026. The company is also expanding the application of its siRNA technology to colorectal cancer models, reflecting its broader ambitions to target multiple KRAS-driven cancers, which are notoriously difficult to treat with conventional therapies. While stock price has pulled back since premarket, The spike in Silexion’s market activity as marked by these record high volumes (according to market data) may highlight the growing market interest in the company’s novel approach to tackling cancers with high unmet medical needs, particularly its focus on KRAS mutations, which are common across a variety of aggressive cancers, including pancreatic and colorectal cancer. Silexion’s continued momentum in the precision oncology space potentially positions it as a leading player in the development of next-generation RNAi therapies. With its promising pipeline and recent positive developments, the company seems to be gaining attention as it advances toward clinical trials that could offer new hope for patients battling some of the deadliest cancers. Click here to read Silexion's full announcement *** This update is for informational purposes only and is not intended to serve as financial, investment or any form of professional advice, recommendation or endorsement. Please review the full documentation detailing financial compensation disclosures and disclaimers the article is subject to. [https://justpaste.it/ab9dn/pdf]. Global Markets News Network is a commercial digital brand compensated to provide coverage of news and developments related to innovative companies as detailed in the full documentation and it is thus subject to conflicts of interest. Contact Details News Coverage ronald@futuremarketsresearch.com

October 01, 2024 11:47 AM Eastern Daylight Time

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Xtreme Trucking Selects HOPTEK’s Dispatch Engine® Solution for Real-Time Visibility and Optimization of Fleet Operations

Hoptek

HOPTEK, a global leader in AI-driven trucking and fleet transportation solutions, has been selected by Xtreme Trucking of Wisconsin, one of the U.S.’s leading technology-first transportation and logistics providers, for its Dispatch Engine® solution, a digital platform providing instant visibility and access to the spot load market, while matching available carrier capacity across thousands of possible options. HOPTEK’s “digital twin” will provide real-time visibility and enable Xtreme to boost operational efficiency and fleet utilization, while reducing driver turnover and deadhead miles, resulting in material cost savings and profitability. Started as a small independent operation in 2006, Xtreme Trucking was formally established in 2009 to become a quality diversified transportation provider, with a growing revenue profile and extensive coverage across the United States. Through HOPTEK’s Dispatch Engine®, Xtreme has leveraged real-time data visibility and dynamic decision-making to drive operational velocity to achieve up to a 20% increase in both Revenue per Hour and Weekly Revenue Miles per Driver – a clear competitive advantage. Travis Nelson, President and Founder of Xtreme Trucking said: “Between supply chain complications, market shifts, and driver shortages, the past several years have been a rollercoaster ride for our industry. Selecting HOPTEK’s Dispatch Engine solution addresses several seemingly intractable challenges, enabling us to optimize fleet utilization, increase driver satisfaction, and reduce deadhead empty miles. HOPTEK’s robust visibility platform enables us to make the best available decision, even as fleets remain dynamic, and routing and load scenarios shift constantly. We at Xtreme immediately recognized the value of HOPTEK’s strategic offering to our operation and how it would support the achievement of our goals.” Transportation and logistics are the backbone of the U.S. economy. Xtreme fuels that economic growth by delivering best-in-class operations, innovative technology solutions, and a talented workforce. The company was seeking a solution that would address very specific issues related to driver miles, route efficiency, and utilization in one platform. Achieving these goals required a unique set of capabilities. HOPTEK’s Dispatch Engine® solution closes these gaps by creating dispatchable recommendations that consider the entire fleet, at any given moment. It gets critical information to dispatchers, planners, drivers, and other stakeholders in near real-time, supercharging efficiencies and profitability. Balaji Guntur, CEO and Co-founder of HOPTEK said: “We’re excited and honored to have been selected as a long-term partner to Xtreme Trucking. Their keen eye for innovative technologies and solutions that genuinely add measurable value attests to why the industry will view Xtreme as a trend setter and leader in small to mid-size fleet tech adoption. We believe they have selected a solution that will enable them to achieve their technology goals, while at the same time supporting their efficiency mindset and profitability targets.” —Ends— About Xtreme Xtreme Trucking LLC delivers superior reefer transportation and dedicated services across the United States. With a leading view on technology and a modern truck and trailer fleet, we are an essential solutions provider for customers who value the integrity of their supply chain and require safe, and exceptional service. Moreover, Xtreme strives for leading on-time delivery and customer service, and as a technologically minded fleet, and remains deeply committed to promoting both customer and driver satisfaction. To find out how Xtreme Trucking Delivers, please visit: https://www.xtremetrucking.com/ About Kearney Kearney is a leading global management consulting firm. For nearly 100 years, we have been the trusted advisor to C-suites, government bodies, and nonprofit organizations. Our people make us who we are. Driven to be the difference between a big idea and making it happen, we help our clients break through. For more information, please visit: https://www.kearney.com/ About HOPTEK HOPTEK was founded in 2021 when global strategy and management consultancy Kearney brought its transportation and tech expertise together to help transform the trucking industry. After HOPTEK’s AI-powered system helped a leading U.S. fleet solve major operational challenges and drastically boost their performance, the company opened that technology to fleets across the U.S. With transformational technology tools such as Fleet Scanner®, Freight Finder®, and Dispatch Engine®, trucking and logistics companies can actively analyze fleet performance, identify and reduce wasteful wait times, and optimize dispatching in responsive real-time. For more information, please visit: https://www.HOPTEK.ai/ Contact Details Sean Maharaj Sean.Maharaj@hoptek.ai

September 23, 2024 09:00 AM Eastern Daylight Time

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Industry Update: 3 Exciting Precision Oncology Players to Watch Following Summit’s Meteoric Rise: Silexion, Nuvectis, Scorpian

Global Markets News

Summit Therapeutics (NASDAQ: SMMT) recently captured headlines with the release of its Phase 3 data for ivonescimab, a targeted NSCLC therapy that has generated substantial buzz. The results from its trial conducted in China showed a dramatic 49% reduction in the risk of disease progression or death compared to Merck’s Keytruda, signaling a potentially disruptive force in NSCLC treatment. However, the news wasn’t without its concerns—since the trial data originates from China, there are questions about its applicability to broader, global populations. As noted by BMO Capital Markets’ Evan Seigerman: “Results may or may not be generalizable beyond the China-focused patient population initially assessed.” Despite this, Summit’s valuation has risen by over 100%, now approximating $19 billion. With such a high valuation, the company could see limited room for further significant gains, leading many in the industry to explore other emerging opportunities in precision oncology. Alongside Summit, there are quite a few other players in the field. Some if these companies have even already shown promising initial results and could see similar success in the future if they were to report positive results. These emerging players are worth watching for those interested in following precision oncology drug candidates and pipelines. Among them are precision oncology innovators such as Silexion Therapeutics, Nuvectis Pharma, and Scorpion Therapeutics, which we discuss below. Silexion Therapeutics: Disrupting the KRAS-Driven Cancer Space Silexion Therapeutics (NASDAQ: SLXN) is another under-the-radar player in the precision oncology space, with a focus on KRAS-driven cancers—a notoriously difficult target in oncology. While current small-molecule KRAS inhibitors are making progress, they are often limited to specific mutations, such as KRAS G12C, which accounts for a small percentage of cancers. Silexion’s RNA interference (RNAi) approach offers a broader solution, targeting a wider spectrum of KRAS mutations, particularly in pancreatic cancer, one of the deadliest and most treatment-resistant cancers. At the heart of Silexion’s approach is its LODER™ platform, which delivers siRNA directly to the tumor site, silencing KRAS mutations at the genetic level. This localized delivery not only increases efficacy by concentrating the treatment in the tumor, but it also reduces systemic side effects. Silexion’s next-generation candidate, SIL-204, is an optimized siRNA formulation designed to target pan-KRAS G12x mutations, positioning it to treat a broader range of KRAS-driven cancers beyond pancreatic cancer, such as lung and colorectal cancers. In Phase 2 trials for locally advanced pancreatic cancer, Silexion's LODER™ platform showed a 9.3-month improvement in overall survival when combined with standard chemotherapy. Additionally, the objective response rate (ORR) increased from 20% with chemotherapy alone to 55% with the combination, and in some cases, tumors that were initially non-resectable became operable after treatment with LODER™. These results are especially encouraging given the limited options available for pancreatic cancer patients. SIL-204, is expected to enter Phase 2/3 clinical trials in 2025-2026. What makes Silexion particularly intriguing is its current market valuation. Valued at aproximatly just ~$9 million following its SPAC merger, the company’s valuation could be perceived as low when compared to some of its peers, especially given its innovative technology and promising clinical achievements. Some have wondered whether this low valuation has more to do with dynamics post-SPAC companies. If Silexion can report positive results in its later-stage trials, the company’s outlook could dramatically improve, reflecting the potential of its RNAi-based platform. Like NXP900, SIL-204 could potentially have vast applications across multiple KRAS-driven cancer types, making Silexion a company to watch closely as it advances through clinical development. Nuvectis Pharma: Targeting NSCLC and Beyond by Inhibiting SRC/YES1 Kinases Nuvectis Pharma (NASDAQ: NVCT) has been quietly making strides in the precision oncology sector, developing innovative therapies aimed at overcoming treatment resistance in hard-to-treat cancers. Its lead candidate, NXP900, targets NSCLC by inhibiting the SRC/YES1 kinases, which play critical roles in cancer cell survival and resistance to current therapies. This approach positions NXP900 as a potential game-changer in the treatment of NSCLC, particularly in patients who have developed resistance to EGFR and ALK inhibitors, such as AstraZeneca’s Tagrisso and Novartis’ Alecensa. NXP900 is still in the early stages of clinical development, currently undergoing Phase 1 trials. However, preclinical studies have already shown that it has strong anti-tumor activity in resistant NSCLC models. Even more promising is its potential application beyond NSCLC. Like Summit's ivonescimab, NXP900 focuses on resistance, but it also has broader applications due to its ability to target multiple cancer types driven by SRC/YES1 pathways. This versatility makes it a promising asset not just for NSCLC but also for other difficult-to-treat cancers like squamous cell carcinomas. In addition to NXP900, Nuvectis is advancing NXP800, another precision oncology candidate that is further along in the clinical development process. NXP800 is currently in Phase 1b trials, targeting ARID1a-mutated cancers such as ovarian and endometrial cancers. The early clinical data for NXP800 is promising, showing positive responses in patients with platinum-resistant ovarian cancer. With two strong candidates in the pipeline, Nuvectis is positioning itself as a formidable player in the precision oncology landscape. As Summit’s ivonescimab continues to gain attention, Nuvectis’ earlier-stage NXP900, with its NSCLC focus and beyond, could see similar success in the future if clinical results continue to trend positively. Scorpion Therapeutics: Pioneering Mutant-Selective Therapies Scorpion Therapeutics is redefining the frontier of precision oncology with its focus on delivering highly selective small molecules targeting validated and previously undruggable cancer mutations. Its lead candidate, STX-478, is a mutant-selective, allosteric PI3Kα inhibitor currently in Phase 1/2 trials for advanced solid tumors. Early data presented at the ESMO Congress 2024 highlighted its potential, with STX-478 demonstrating a 23% overall response rate in breast cancer and a 21% response rate across all tumor types, positioning it as a potentially best-in-class PI3Kα inhibitor. STX-478 is notable for its ability to spare wild-type PI3Kα activity in normal tissues, avoiding the toxicities seen with previous PI3Kα inhibitors, such as hyperglycemia and rash. Tumor reductions were seen in 72% of patients treated with STX-478 as a monotherapy, with circulating tumor DNA levels dropping in 86% of patients. This mutant-selective precision could help overcome the limitations of existing PI3Kα inhibitors, which have struggled with dose-limiting toxicities. In July 2024, Scorpion raised $150 million in a Series C financing round, co-led by Frazier Life Sciences and Lightspeed Venture Partners. The additional funding will support the advancement of STX-478 and other pipeline assets, positioning Scorpion for further clinical success. Scorpion’s pipeline includes a broad range of wholly-owned compounds that target both validated and novel cancer targets, positioning the company for future expansion into larger patient populations. As STX-478 progresses through clinical development, Scorpion is poised to become a significant player in the precision oncology space, making it another company worth watching closely. Optimistic Outlook for Precision Oncology The precision oncology space is experiencing a golden era of innovation, with companies like Summit Therapeutics, Nuvectis Pharma, Silexion Therapeutics, and Scorpion Therapeutics leading the charge. As the focus shifts towards targeted therapies that address resistance mechanisms, the market is increasingly favoring companies with novel approaches and broad applications. Summit’s meteoric rise has shown that there is tremendous potential for companies that can demonstrate efficacy in overcoming cancer resistance. While Summit has already captured much of the current attention, companies like Nuvectis, Silexion, and Scorpion, with their earlier-stage pipelines, offer exciting opportunities for the industry to keep a close eye on. As these companies continue to report clinical data and advance through trials, the potential for breakthroughs in treating some of the most difficult cancers grows stronger. With targeted therapies offering the possibility of overcoming resistance without the need for chemotherapy, the future of cancer treatment looks brighter than ever. For those in the oncology space, keeping a close eye on emerging players like Nuvectis, Silexion, and Scorpion could lead to transformative developments as the field of precision oncology continues to evolve. * * * This update may include speculative forward looking statements. Readers are cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, and that actual results may differ materially from those in the forward-looking statements as a result of various factors. the BioTech and Pharma industries are volatile and risky and readers are advised to seek out preffesional advice in the relevent feilds from licensed profesionals. This update is for informational purposes only and is not intended to serve as financial, investment or any form of professional advice, recommendation or endorsement. Please review the full documentation detailing financial compensation disclosures and disclaimers the article is subject to. [ https://justpaste.it/ch2qt/pdf ]. Global Markets News Network is a commercial digital brand compensated to provide coverage of news and developments related to innovative companies as detailed in the full documentation and it is thus subject to conflicts of interest. Contact Details News Coverage ronald@futuremarketsresearch.com

September 19, 2024 07:45 AM Eastern Daylight Time

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Join Benchmark International's Exclusive Webinar "Seller Motivation: What Goes Into the Decision to Sell?"

Benchmark International

Are you considering selling your business? Deciding when and why to sell is one of the most significant decisions you’ll ever make as a business owner. While maximizing financial proceeds is often at the forefront of these decisions, it’s essential to recognize that it’s not the only factor. Life circumstances, time with family, and other qualitative considerations can often outweigh financial gain. To help you navigate this complex process, we invite you to join our upcoming webinar: Seller Motivation: What Goes Into The Decision To Sell? Space is filling up fast, so register today! Why You Should Register Selling a business is about more than just crunching the numbers. In this exclusive webinar, you’ll gain valuable insights into the full spectrum of motivations that drive business owners to sell. Understanding these motivations can help you make a well-rounded and informed decision about your business’s future. This webinar is a must-attend for business owners contemplating the sale of their business, particularly in today’s strong but disciplined market. By attending, you’ll be better equipped to evaluate both the financial and personal factors that play a crucial role in this life-changing decision. Whether you’re focused on securing a comfortable financial future or prioritizing time with loved ones, the information presented will help you weigh these considerations effectively. Spots are limited, so don’t miss this opportunity to secure your spot. What You’ll Learn This webinar offers actionable insights into the decision-making process for business owners. Here’s what you can expect to learn: The wide range of reasons why business owners choose to sell, beyond just financial incentives How personal life events, such as family needs and future aspirations, can influence your decision A look at the current M&A market and how buyers are approaching valuations How to balance personal and financial goals using the concept of indifference curves, which help weigh non-monetary values like time with family against financial returns By attending, you’ll gain the tools to make a decision that aligns with your long-term vision—both personally and financially. Spots Are Filling Fast – Register Now! If you’re ready to gain clarity on your motivations for selling and align your decision with both your personal and financial goals, this is the webinar for you. Don’t miss out—register now and take the first step toward making a well-informed, strategic decision about the future of your business. ABOUT BENCHMARK INTERNATIONAL: Benchmark International is a global M&A firm that provides business owners with creative, value-maximizing solutions for growing and exiting their businesses. Benchmark International has handled over $11 billion in transaction value across various industries from offices across the world. With decades of M&A experience, Benchmark International’s transaction teams have assisted business owners with achieving their objectives and ensuring the continued growth of their businesses. The firm has also been named the Investment Banking Firm of the Year by The M&A Advisor and the Global M&A Network as well as the #1 Sell-side Exclusive Privately-held M&A Advisor in the World by Pitchbook and Refinitiv's Global League Tables. Contact Details Brittney Zoeller +1 813-898-2350 zoeller@benchmarkintl.com Company Website https://www.benchmarkintl.com/

September 16, 2024 09:54 AM Eastern Daylight Time

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Leading Beauty Retailer Credo Beauty Debuts Private Label Skincare Line: Credo Skincare

Credo Beauty

Credo, the specialty clean beauty retail pioneer, is proud to announce the launch of its own eponymous skincare line, Credo Skincare. The specialty retailer has raised the bar introducing a benefit-driven collection of skincare products focused on the #1 skin concern gathered from clients – hydration – while continuing to challenge and elevate standards for clean and sustainable products and packaging. A cohesive easy to navigate cleanser and moisturizer system meets wanted gold standards. A decade ago, Credo disrupted an underregulated industry as a catalyst for positive change spurring a tidal wave of conscientious product and packaging innovation. Now after accruing 10 years of customer feedback, experience, and data Credo Skincare was developed according to what they found matters most. Ultimately hydration was the stand-out concern for clients. And through in-depth analysis, Credo determined the top ingredient and search terms according to what customers want from their products to deliver that and more. Through their access to the best in business partners, they created results-driven formulas packed with clinically proven actives and sustainably- minded packaging - every aspect of Credo Skincare is transparent and powerfully effective. Credo Skincare’s first collection is comprised of two cleansers ($44 each) and four moisturizers ($64 each) that service skin conditions surrounding primary concerns - dry skin, sensitivity and redness, dullness, and aging - by nourishing the skin and protecting its microbiome through today’s most powerful active combinations. Their formulations are based on key ingredient search terms and skincare concerns. As well, each product contains the transformative power of upcycled vetiver root extract, ethically harvested by a local cooperative in Haiti. Vetiver root is an antioxidant-loaded, potent wonder grass that supports the protection of the skin’s barrier for a vibrant skin tone and a nourished complexion while improving skin texture and reducing the appearance of pores and wrinkles. Credo Skincare’s goals are to provide an easy two step, effective regimen for healthy, hydrated skin that makes customers look and feel their best. Clinicals have proven 27% improvement in hydration after 24 hours, 31% improvement in hydration instantly, and an improvement in the skin barrier function instantly and after 24 hours. ● Deep Thirst Hydrating Cleanser ($44): A transformative formula to deeply cleanse while retaining moisture. ● True Timeout Calming Cleanser ($44): Designed to soothe and calm sensitive skin. ● Deep Thirst Hydrating Moisturizer ($64): Provides intense hydration with lasting effects. ● True Timeout Calming Moisturizer ($64): Helps alleviate sensitivity and redness. ● Radiance Rising Brightening Moisturizer ($64): Brightens dull skin and enhances radiance. ● Rewinder Anti-Aging Moisturizer ($64): Reduces the appearance of wrinkles and fine lines. Beyond that as a retailer, Credo Beauty continues to drive the packaging and social standards that are the hallmarks of tomorrow. Every pump and cap in the Credo Skincare collection is comprised of a first-of-its kind PCR resin, including beauty waste packaging collected in Credo Beauty stores nationwide through Pact Collective, the non-profit Credo Beauty co-founded to divert beauty packaging from landfills. ● The Credo pump was created with Pact’s NewMatter material, a mixture of hard-to-recycle material or landfill and ocean-bound plastic. ● The first run of NewMatter pumps eliminated the need for 500 kg of virgin plastic (500 kg of recycled plastic used is equivalent to 11 cubic meters of landfill space or ~2,900 gallons of space!) ​ ● Every 38 pumps eliminate one pound of material going to the landfill or ocean.​ “The benefit of listening to 10 years of customers' desires and skin concerns compelled us to create this line. Years of data drove the ingredient compositions of these products so that we could exceed our customers’ expectations for efficacy. Our Credo Clean Standard is already rigorous and difficult to attain but we wanted to challenge ourselves with how our own brand could take clean innovation to new heights from full disclosure of fragrance ingredients and packaging innovation to exceeding the minimum requirements to check certain boxes, Credo Skincare raises the bar on what is possible and what can become the future baseline,” says Co-Founder and CEO Annie Jackson. Availability: Credo Skincare will be available for purchase starting September 12, 2024, at all Credo brick and mortar store locations and on www.credobeauty.com. Media Contact: press@credobeauty.com About Credo Beauty: Credo Beauty offers today’s largest clean and sustainably minded beauty assortment in North America, across color, skincare, haircare and fragrance, partnering with over 120 leading brands, such as Westman Atelier, ILIA, OSEA, True Botanicals and LolaVie. Having built the strictest and lengthy guidelines, “The Credo Clean Standard™”, customers can trust that they are purchasing the most effective, innovative products with safer ingredients with an emphasis on sustainable, natural and ethical materials. Trained makeup artists and estheticians (who are continually being educated by Credo Beauty and our brands) offer an exceptional experience both in-store and online. Visit one of the 15 brick-and-mortar store locations or www.credobeauty.com. Credo Beauty is backed by Next World Evergreen, a San Francisco-based private equity firm that invests in conscious consumer brands across sectors like clean beauty, personal care, health and wellness, sustainable lifestyle, and better-for-you food and beverage. Visit https://www.nextworldevergreen.com/ About Pact Collective: With an industry that generates over 120 billion packages every year, most ending up in landfill – they’re often too small, too flexible, or made of too many materials to be traditionally recycled. All those tiny cosmetic contraptions? They’re headed for the trash. Pact is a nonprofit collective uniting the beauty industry to take responsibility for our packaging waste and work collaboratively toward circular packaging solutions. Visit https://www.pactcollective.org/ Contact Details Amanda Smeal +1 844-692-7336 press@credobeauty.com

September 12, 2024 08:04 AM Eastern Daylight Time

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