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Industry Update: 3 Exciting Precision Oncology Players to Watch Following Summit’s Meteoric Rise: Silexion, Nuvectis, Scorpian

Global Markets News

Summit Therapeutics (NASDAQ: SMMT) recently captured headlines with the release of its Phase 3 data for ivonescimab, a targeted NSCLC therapy that has generated substantial buzz. The results from its trial conducted in China showed a dramatic 49% reduction in the risk of disease progression or death compared to Merck’s Keytruda, signaling a potentially disruptive force in NSCLC treatment. However, the news wasn’t without its concerns—since the trial data originates from China, there are questions about its applicability to broader, global populations. As noted by BMO Capital Markets’ Evan Seigerman: “Results may or may not be generalizable beyond the China-focused patient population initially assessed.” Despite this, Summit’s valuation has risen by over 100%, now approximating $19 billion. With such a high valuation, the company could see limited room for further significant gains, leading many in the industry to explore other emerging opportunities in precision oncology. Alongside Summit, there are quite a few other players in the field. Some if these companies have even already shown promising initial results and could see similar success in the future if they were to report positive results. These emerging players are worth watching for those interested in following precision oncology drug candidates and pipelines. Among them are precision oncology innovators such as Silexion Therapeutics, Nuvectis Pharma, and Scorpion Therapeutics, which we discuss below. Silexion Therapeutics: Disrupting the KRAS-Driven Cancer Space Silexion Therapeutics (NASDAQ: SLXN) is another under-the-radar player in the precision oncology space, with a focus on KRAS-driven cancers—a notoriously difficult target in oncology. While current small-molecule KRAS inhibitors are making progress, they are often limited to specific mutations, such as KRAS G12C, which accounts for a small percentage of cancers. Silexion’s RNA interference (RNAi) approach offers a broader solution, targeting a wider spectrum of KRAS mutations, particularly in pancreatic cancer, one of the deadliest and most treatment-resistant cancers. At the heart of Silexion’s approach is its LODER™ platform, which delivers siRNA directly to the tumor site, silencing KRAS mutations at the genetic level. This localized delivery not only increases efficacy by concentrating the treatment in the tumor, but it also reduces systemic side effects. Silexion’s next-generation candidate, SIL-204, is an optimized siRNA formulation designed to target pan-KRAS G12x mutations, positioning it to treat a broader range of KRAS-driven cancers beyond pancreatic cancer, such as lung and colorectal cancers. In Phase 2 trials for locally advanced pancreatic cancer, Silexion's LODER™ platform showed a 9.3-month improvement in overall survival when combined with standard chemotherapy. Additionally, the objective response rate (ORR) increased from 20% with chemotherapy alone to 55% with the combination, and in some cases, tumors that were initially non-resectable became operable after treatment with LODER™. These results are especially encouraging given the limited options available for pancreatic cancer patients. SIL-204, is expected to enter Phase 2/3 clinical trials in 2025-2026. What makes Silexion particularly intriguing is its current market valuation. Valued at aproximatly just ~$9 million following its SPAC merger, the company’s valuation could be perceived as low when compared to some of its peers, especially given its innovative technology and promising clinical achievements. Some have wondered whether this low valuation has more to do with dynamics post-SPAC companies. If Silexion can report positive results in its later-stage trials, the company’s outlook could dramatically improve, reflecting the potential of its RNAi-based platform. Like NXP900, SIL-204 could potentially have vast applications across multiple KRAS-driven cancer types, making Silexion a company to watch closely as it advances through clinical development. Nuvectis Pharma: Targeting NSCLC and Beyond by Inhibiting SRC/YES1 Kinases Nuvectis Pharma (NASDAQ: NVCT) has been quietly making strides in the precision oncology sector, developing innovative therapies aimed at overcoming treatment resistance in hard-to-treat cancers. Its lead candidate, NXP900, targets NSCLC by inhibiting the SRC/YES1 kinases, which play critical roles in cancer cell survival and resistance to current therapies. This approach positions NXP900 as a potential game-changer in the treatment of NSCLC, particularly in patients who have developed resistance to EGFR and ALK inhibitors, such as AstraZeneca’s Tagrisso and Novartis’ Alecensa. NXP900 is still in the early stages of clinical development, currently undergoing Phase 1 trials. However, preclinical studies have already shown that it has strong anti-tumor activity in resistant NSCLC models. Even more promising is its potential application beyond NSCLC. Like Summit's ivonescimab, NXP900 focuses on resistance, but it also has broader applications due to its ability to target multiple cancer types driven by SRC/YES1 pathways. This versatility makes it a promising asset not just for NSCLC but also for other difficult-to-treat cancers like squamous cell carcinomas. In addition to NXP900, Nuvectis is advancing NXP800, another precision oncology candidate that is further along in the clinical development process. NXP800 is currently in Phase 1b trials, targeting ARID1a-mutated cancers such as ovarian and endometrial cancers. The early clinical data for NXP800 is promising, showing positive responses in patients with platinum-resistant ovarian cancer. With two strong candidates in the pipeline, Nuvectis is positioning itself as a formidable player in the precision oncology landscape. As Summit’s ivonescimab continues to gain attention, Nuvectis’ earlier-stage NXP900, with its NSCLC focus and beyond, could see similar success in the future if clinical results continue to trend positively. Scorpion Therapeutics: Pioneering Mutant-Selective Therapies Scorpion Therapeutics is redefining the frontier of precision oncology with its focus on delivering highly selective small molecules targeting validated and previously undruggable cancer mutations. Its lead candidate, STX-478, is a mutant-selective, allosteric PI3Kα inhibitor currently in Phase 1/2 trials for advanced solid tumors. Early data presented at the ESMO Congress 2024 highlighted its potential, with STX-478 demonstrating a 23% overall response rate in breast cancer and a 21% response rate across all tumor types, positioning it as a potentially best-in-class PI3Kα inhibitor. STX-478 is notable for its ability to spare wild-type PI3Kα activity in normal tissues, avoiding the toxicities seen with previous PI3Kα inhibitors, such as hyperglycemia and rash. Tumor reductions were seen in 72% of patients treated with STX-478 as a monotherapy, with circulating tumor DNA levels dropping in 86% of patients. This mutant-selective precision could help overcome the limitations of existing PI3Kα inhibitors, which have struggled with dose-limiting toxicities. In July 2024, Scorpion raised $150 million in a Series C financing round, co-led by Frazier Life Sciences and Lightspeed Venture Partners. The additional funding will support the advancement of STX-478 and other pipeline assets, positioning Scorpion for further clinical success. Scorpion’s pipeline includes a broad range of wholly-owned compounds that target both validated and novel cancer targets, positioning the company for future expansion into larger patient populations. As STX-478 progresses through clinical development, Scorpion is poised to become a significant player in the precision oncology space, making it another company worth watching closely. Optimistic Outlook for Precision Oncology The precision oncology space is experiencing a golden era of innovation, with companies like Summit Therapeutics, Nuvectis Pharma, Silexion Therapeutics, and Scorpion Therapeutics leading the charge. As the focus shifts towards targeted therapies that address resistance mechanisms, the market is increasingly favoring companies with novel approaches and broad applications. Summit’s meteoric rise has shown that there is tremendous potential for companies that can demonstrate efficacy in overcoming cancer resistance. While Summit has already captured much of the current attention, companies like Nuvectis, Silexion, and Scorpion, with their earlier-stage pipelines, offer exciting opportunities for the industry to keep a close eye on. As these companies continue to report clinical data and advance through trials, the potential for breakthroughs in treating some of the most difficult cancers grows stronger. With targeted therapies offering the possibility of overcoming resistance without the need for chemotherapy, the future of cancer treatment looks brighter than ever. For those in the oncology space, keeping a close eye on emerging players like Nuvectis, Silexion, and Scorpion could lead to transformative developments as the field of precision oncology continues to evolve. * * * This update may include speculative forward looking statements. Readers are cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, and that actual results may differ materially from those in the forward-looking statements as a result of various factors. the BioTech and Pharma industries are volatile and risky and readers are advised to seek out preffesional advice in the relevent feilds from licensed profesionals. This update is for informational purposes only and is not intended to serve as financial, investment or any form of professional advice, recommendation or endorsement. Please review the full documentation detailing financial compensation disclosures and disclaimers the article is subject to. [ https://justpaste.it/ch2qt/pdf ]. Global Markets News Network is a commercial digital brand compensated to provide coverage of news and developments related to innovative companies as detailed in the full documentation and it is thus subject to conflicts of interest. Contact Details News Coverage ronald@futuremarketsresearch.com

September 19, 2024 07:45 AM Eastern Daylight Time

Comcast to Expand Fiber Broadband Services Across Northern California

Comcast California

Comcast announced it will expand its reliable, smart, high-speed, fiber broadband network in both residential and commercial neighborhoods in Northern California’s Marin and Sutter counties. By mid-2026 these expansion efforts will bring Comcast’s next-generation network to over 150 locations in Marin County and over 450 locations in Sutter County, both of which had previously been unserved. This broadband network expansion is made possible by a $14 million Federal Funding Account (FFA) Grant from the California Public Utilities Commission (CPUC) and private funding by Comcast. Comcast also recently announced it has received a $26 million FFA grant to expand its fiber-rich network in Tulare County, which will bring broadband services to nearly 6,200 unserved locations by early 2026. “At Comcast we understand that reliable, high-speed Internet has become a necessity to not only support those looking to participate in the ever-growing digital economy, but also to connect students, families and seniors to those moments that matter the most,” said David Tashjian, Regional Senior Vice President of Comcast California. “This continued investment of funds from the California Public Utilities Commission (CPUC) will allow us to expand into unserved communities throughout Marin and Sutter Counties, which will provide residents and businesses with a future of unlimited possibilities.” “This grant project will help level the playing field for a lot of families in Sutter County who have not previously had access to high-speed Internet,” said Mat Conant, Chair of the Sutter County Board of Supervisors. “This is really important for anyone doing any research for school or work, and for small business owners.” “There has always been an overwhelming demand to improve and expand our broadband services in Marin County,” said Eric Lucan of the Marin County Board of Supervisors. “That need is particularly important for our senior community, including my constituents within a mobile home community in Novato. I commend the California Public Utilities Commission (CPUC) and Comcast on today’s announcement and I’m excited to see the lasting impacts these awards will have in connecting more residents to high-speed Internet and the economic opportunities they will create.” Comcast’s commitment to new communities goes beyond network expansion efforts, addressing digital opportunities in communities through Project UP, the company’s $1 billion dollar commitment to help tens of millions of people connect to the Internet and build futures of unlimited possibilities. Over the past three years, Comcast has invested more than $130 million in cash and in-kind donations into California nonprofits focused on helping people build digital skills, expanding WiFi connected Lift Zones and funding connectivity and Internet adoption programs. Comcast’s funding also supports ongoing efforts to build awareness about affordable connectivity services like Internet Essentials, which offers eligible households high-speed Internet for $9.95/month or Internet Essentials Plus for $29.95/month. Affordable computers are also available through Internet Essentials. Since its inception in 2011, the program has connected more than 2.2 million Californians. Residential customers will be able to take advantage of Xfinity’s full suite of products, including Internet, video, mobile, voice and managed home solutions. For local businesses, Comcast Business will offer a suite of connectivity, communications, networking, cybersecurity, wireless, and managed solutions to help organizations of different sizes prepare for what’s next. Industry analysts and associations have consistently recognized Comcast Business as a leader and innovator, and one of the fastest-growing providers of Ethernet services. Comcast’s network and Internet experience are powering homes today and into the future. Ultimate Capacity: Xfinity customers connect more than 1 billion devices across the company’s network annually. With the next-generation Xfinity gateways, we deliver the most advanced WiFi technology carrying three times more bandwidth to power streaming, gaming, videoconferencing, and more, simultaneously. Fastest Internet: Nearly a third of Xfinity Internet customers subscribe to gigabit speed products. Recently Comcast connected the first customers in the world to a DOCSIS 4.0 connection, delivering symmetrical gig speeds over existing connections in customers’ homes with plans to continue to rollout these speeds across the country over the coming years. Unprecedented Coverage: The latest Xfinity Gateway provides a more reliable connection throughout the home. Customers can get wall-to-wall WiFi coverage with a powerful WiFi Boost Pod that extends coverage to hard-to-reach areas of the home. Most Reliable Connection: Comcast is scaling the nation’s largest and most reliable network that passes 62 million homes and businesses and counting. The company launched Storm-Ready WiFi, a new device that comes powered with cellular and battery backup to help keep customers connected even when the power goes out. Ultra-Low Latency: The Xfinity network and the latest Xfinity Gateway are a powerful combination that deliver ultra-low latency for those moments when response times matter most like video games, a fast-growing category with Xfinity households averaging more than one gaming console per home. For local businesses, Comcast Business will offer a suite of connectivity, communications, networking, cybersecurity, wireless, and managed solutions to help organizations of different sizes prepare for what’s next. Comcast Business has been consistently recognized by industry analysts and associations as a leader and innovator, and one of the fastest-growing providers of Ethernet services. ### About Comcast Business Comcast Business offers leading global businesses the technology solutions and forward-thinking partnership they need. With a full suite of solutions including fast, reliable connectivity, secure networking solutions and advanced cybersecurity and a range of managed service options, Comcast Business is ready to meet the needs of businesses of all sizes. Comcast Business has been recognized by leading analyst firms for its continued growth, innovation, and leadership, and is committed to partnering with customers to help them drive their businesses forward. For more information, call 800-501-6000. Follow @ComcastBusiness on social media networks at http://business.comcast.com/social. About Comcast Corporation Comcast Corporation (Nasdaq: CMCSA) is a global media and technology company. From the connectivity and platforms we provide, to the content and experiences we create, our businesses reach hundreds of millions of customers, viewers, and guests worldwide. We deliver world-class broadband, wireless, and video through Xfinity, Comcast Business, and Sky; produce, distribute, and stream leading entertainment, sports, and news through brands including NBC, Telemundo, Universal, Peacock, and Sky; and bring incredible theme parks and attractions to life through Universal Destinations & Experiences. Visit www.comcastcorporation.com for more information. Contact Details Comcast California Jon Koriel +1 925-315-2690 jon_koriel@comcast.com Company Website https://california.comcast.com/

September 12, 2024 01:46 PM Pacific Daylight Time

VOESH New York Launches New 28 oz. Vegan Hand & Body Crème Collection

VOESH New York

VOESH New York is debuting a new 28 oz. Vegan Hand & Body Crème Collection, created to provide salon clients with a luxurious and healthier hydration experience. These larger bottles offer the same high-quality, vegan-friendly ingredients that have established VOESH as a leader in the body care industry. “We’re thrilled about the addition of these generously sized lotions to VOESH’s product line,” said Tom Harrison, Principal of Coleman Harrison. “VOESH consistently outshines the competition with expert formulas. This new size will undoubtedly enhance manicure and pedicure services, delivering superior results for both clients and technicians.” “As a bonus, technicians can pair these lotions with VOESH’s best-selling Pedi in a Box products,” added Kendall Stone, Principal of Jay Stone Sales. Enriched with 94+% natural-origin ingredients, VOESH’s 28 oz. crèmes are formulated with organic virgin olive oil and natural extracts. They are infused with 100% vegan, clean, and certified organic components and are free from parabens, phthalates, gluten, mineral oil, and more than 1,680 other potentially harmful substances. The velvety texture provides long-lasting moisture and a radiant glow without a greasy feel. These larger bottles not only provide a superior experience but also ensure lasting hydration and value. “Our lotions have always been a best-seller, so we’ve brought them back in a more convenient size for salons,” said Joseph Choi, Co-Founder of VOESH New York. “Salon owners have been asking for our popular massage butter in a bottle, and we’re ecstatic to fulfill this request.” The new collection is available in five delightful scents: Olive Sensation, Lavender Relieve, Vitamin Recharge, Jasmine Soothe, and Green Tea Detox. Each scent is made with premium, IFRA-certified fragrances that pair perfectly with VOESH’s best-selling Pedi in a Box Deluxe 4 Step pedicure kits. This allows for a cohesive pampering experience that caters to clients’ preferences. With a transparent ingredient list, dermatologist testing, and U.S. FDA registration, VOESH’s new 28 oz. Vegan Hand & Body Crèmes are the best addition to guarantee clients and technicians feel good about what goes on their skin. For more information about VOESH’s new 28 oz. Vegan Hand & Body Crèmes, please visit voeshpro.com. About VOESH New York: Founded in 2013, VOESH New York has emerged as a premier destination for clean and efficacious body care solutions catering to head-to-toe wellness. Noteworthy products include Pedi in a Box, Mani in a Box, the award-winning Shower & Empower Vitamin C Shower Filter, and Collagen Gloves and Socks. VOESH New York is committed to providing 100% vegan, cruelty-free, and sustainable products because every body deserves better beauty! All VOESH New York products are certified by PETA and registered with the US Mocra, EU CPNP and UK SCPN, maintaining vegan, cruelty-free, and dermatologist-tested standards. VOESH New York proudly excludes all 1,680+ EU-banned ingredients and an additional 400+ potentially harmful ingredients. For more information, visit VOESH New York’s website at Voesh.com or contact press@voesh.com. All VOESH New York products are certified by PETA and registered with the EU CPNP, and UK SCPN. Always vegan, cruelty-free, and dermatologist-tested, VOESH New York proudly excludes all 1,680+ EU-banned ingredients and an additional 400+ potentially harmful ingredients. Contact Details Colleen Mathis +1 917-690-5560 Colleen@absoluterrelations.com Company Website https://voesh.com/

September 06, 2024 08:00 AM Eastern Daylight Time

News Release

Introducing Brick Media: A New Force in Media Management and Innovation

Full Scope PR

Brick Media announces its powerful entrance into the media landscape, asserting itself as a catalyst for transformation. With a bold vision for content innovation and unparalleled management expertise, Brick Media is set to redefine and lead the charge in shaping the future of media. As a full-service media management firm at the intersection of content strategy and business execution, Brick Media is committed to nurturing the growth and monetization of its clients' careers across the digital media landscape. With a multifaceted approach, the company aims to elevate brands and voices across sports, entertainment, and beyond. Drawing from over a decade of unparalleled success in sports and entertainment management, Aaron & André Eanes of A&A Management bring their strategic expertise and deep industry insights to position Brick Media as a transformative force in the media sector. Leading this ambitious venture alongside them is CEO of Brick Media, Maggie Clifton. Formerly with Blue Wire and Wasserman, Maggie brings a wealth of experience and a visionary outlook to the company. Under her guidance, a team of highly skilled media professionals will spearhead the optimization of innovative and compelling content. Together, they stand ready to redefine the boundaries of the industry, heralding a new era of influence. "We founded Brick Media with the strategic vision of being a vital resource in the media industry for those seeking to elevate their clients' success to new levels. When we helped with the launch of New Heights, it revealed a critical need for an independent partner adept at steering through the intricacies of advertising, ancillary revenue streams, digital creation, and social growth. Brick Media fulfills that role, offering expert guidance and the best-in-class resources to empower achieving maximum value." says Aaron & Andre Eanes of A&A Management Group. "Brick Media is here to support our partners’ media businesses via strategy, monetization, distribution, marketing, and all other opportunities for growth. We’ve been building quietly all year and are excited to finally launch publicly.” says CEO of Brick Media, Maggie Clifton. In a remarkable inaugural achievement, Aaron Eanes of A&A Management Group and Maggie Clifton of Brick Media led negotiations a ground-breaking deal between the leading podcast studio Wondery and the widely acclaimed show, "New Heights with Jason and Travis Kelce," alongside Andre Eanes of A&A Management Group and Jason Bernstein of Clarity Football. This marks the beginning of Brick Media's mission to forge impactful partnerships and deliver unparalleled growth across the digital media landscape. Brick Media is dedicated to pushing the boundaries of creativity and strategic content development. As the company continues to forge influential partnerships and manage transformative projects, Brick Media is poised to become a leader in the digital media ecosystem. About Brick Media Brick Media is a media management firm specializing in content strategy and business development. Dedicated to fostering client growth and monetization across diverse media landscapes, including sports, entertainment, and news, Brick Media is set to make its mark on the future of media. Contact Details Alessandra Chisolm alessandra@fullscopepr.com

September 05, 2024 09:00 AM Eastern Daylight Time

NAVEX Announces 2024 Excellence Awards Finalists

NAVEX Global

NAVEX, a leading provider of integrated risk and compliance management software, announces today the 2024 NAVEX Excellence Awards finalists. Now in its fourth year, the awards celebrate organizations that demonstrate exceptional commitment to corporate governance, risk mitigation, and ethical practices. Each year, the NAVEX Excellence Awards highlight how robust governance, risk and compliance (GRC) programs can strengthen corporate culture and meaningfully impact business outcomes that matter. The 2024 finalists exemplify how effective GRC initiatives can proactively manage and mitigate risks when woven into the organizational fabric. "Congratulations to this year’s nominees and finalists for their outstanding achievements," said NAVEX Chief Customer Officer, Steve Chapman. "We are proud to partner with customers who are dedicated to advancing their GRC efforts. These awards shine a spotlight on some of the most innovative and effective programs in the industry, and we applaud the compliance teams at these companies for their ongoing efforts to build highly ethical, risk-aware organizations." The winners will be honored in several categories, including Ethics & Compliance, Risk Management, and Risk and Compliance Program of the Year. Selected from a highly competitive pool of nominations, this year’s finalists include: As in previous years, the judging panel brings together a mix of NAVEX leaders and seasoned GRC professionals. This year’s esteemed panel features: Barbara Boehler, Senior Director, Program on Corporate Compliance and Ethics, Fordham Law Bill Cameron, Founder and Principal, Cameron Advisory Services Carol Williams, CEO and Enterprise Risk Management Consultant, Strategic Decision Solutions Carrie Penman, Chief Risk and Compliance Officer, NAVEX Kyle Brasseur, Former Editor in Chief, Compliance Week Kyle Martin, Vice President of GRC Solutions, NAVEX Matt Kelly, Editor and CEO, Radical Compliance LLC Stephen Chapman, Chief Customer Officer, NAVEX Vera Cherepanova, Ethics Advocate, Consultant, Author, Studio Etica Award recipients will be announced after to the 2024 NAVEX Next Virtual Conference on October 1. NAVEX is trusted by thousands of customers worldwide to help them achieve the business outcomes that matter most. As the global leader in integrated risk and compliance management software and services, we deliver solutions through the NAVEX One platform, the industry’s most comprehensive governance, risk and compliance (GRC) information system. For more information, visit NAVEX.com and our blog. Follow us on Twitter and LinkedIn. Contact Details Navex Global +1 617-388-5773 scott.levesque@navex.com Company Website https://navex.com

September 03, 2024 08:06 AM Eastern Daylight Time

PRSA Colorado Chapter Announces Winners of the 2024 Gold Picks Awards

PRSA Colorado

The Colorado Chapter of the Public Relations Society of America (PRSA Colorado) hosted its highly anticipated 2024 Gold Picks Awards Ceremony last night at Stick and Feather in Denver, Colo. The event, which has become a cornerstone of the Colorado public relations community, celebrated the outstanding achievements of professionals and organizations in the field of public relations and corporate communications. Honoring Two Pioneers A highlight of the evening was the presentation of Special Awards, including the Jane Dvorak Mentor of the Year Award and the Sharon Linhart PR Person of the Year Award. These awards were renamed at the event in honor of two trailblazers in the Colorado PR community, recognizing their extraordinary contributions to the industry. The 2024 Special Awards winners are: Joe Fuentes Rookie of the Year: Caroline Campbell, VISIT DENVER Jane Dvorak Mentor of the Year Award: Shawna Seldon McGregor, Maverick Public Relations Media Person of the Year: Greg Avery, Denver Business Journal Business Person of the Year: Doyle Albee, Comprise PR Team of the Year: Gomez Howard Group Ayers Chapter Service Award: Liz Viscardi, APR, LV Events and PR Sharon Linhart PR Person of the Year Award: Merideth Hartung, B Public Relations Rising Stars and Industry Leaders The event also shone a spotlight on the next generation of PR professionals. Members of the Public Relations Student Society of America (PRSSA) from the University of Colorado Boulder and Colorado State University were acknowledged for their contributions to the event and their dedication to the profession. The PRSSA's efforts in fundraising and their anticipated participation in the ICON conference in Anaheim, Calif. this fall were particularly commended. 2024 Gold Picks Award Winners All award winners are listed below under their corresponding category. Gold Picks are the highest-scoring awards based on a specific scoring system but each award is judged individually instead of against the other submittals within that category, meaning multiple organizations can win a Gold Pick within the same category. All awards are judged anonymously by another chapter of PRSA. Gold and Silver Pick Awards: Integrated Communications: Consumer Products: Gold: SchroderHaus – "Justin’s Nuts About Bees" Silver: SchroderHaus – "Justin’s #JustinMyLunch Hunger Relief Program" Government: Gold: CIG Public Relations – "Express Lanes Safety Enforcement" Silver: CIG Public Relations – "CDOT’s Cannabis-Impaired Driving Campaign" Associations/Nonprofits/Educational Institutions: Silver: SchroderHaus – "Fairtrade America’s 'We Are Fairtrade.' Awareness Campaign" Events and Observances - Seven or Fewer Days: Government: Gold: National Disabled Veterans Winter Sports Clinic – "Miracles on a Mountainside" Silver: National Renewable Energy Laboratory – "NREL Welcomes Neighbors Back to Campus During Community Open House" Associations/Nonprofits/Educational Institutions: Gold: Meadows PR and Visit Golden – "Goldens in Golden" Silver: CU Boulder Office of Strategic Relations & Communications – "ScienceWriters2023 at CU Boulder" Silver: Metropolitan State University of Denver – "9News Denver Mayoral Debate hosted by MSU Denver" Content Marketing: Government: Silver: CIG Public Relations – "CDOT Motorcycle Safety campaign" Business to Business: Silver: Graebel Companies with Linhart Public Relations – "Amplifying Thought Leadership and Demonstrating Value through Creative Storytelling" Silver: BOK Financial – "Healthcare Cyberattacks Hurt Providers and Patients Alike" Community Relations: Associations/Nonprofits/Educational Institutions: Silver: JKD & Company and The Church of Jesus Christ of Latter-day Saints – "11th Hour Push - Denver’s Giving Machines" Climate Action and Environmental Sustainability: Silver: SideCar Public Relations – "Seizing Streets for Community Not Cars: ¡Viva! Streets Denver Brings a Global Phenomenon to the Mile High City" Influencer Marketing: Micro-Influencers: Silver: SchroderHaus – "Increasing Reach and Credibility through Influencer Partnerships for Clipper Tea" Organizational Awards: Best Agency - Midsize: Gold: B Public Relations – "From Local to Global: B Public Relations Elevates Hospitality Brands and Experiences" Component Awards: Annual Reports: Gold: Western Resource Advocates – "WRA’s 2022 Impact Report - Building a Better West" Gold: JKD & Company – "Native American Bank - Honoring Community" Social Media: Gold: CU Boulder Office of Strategic Relations & Communications – "CU in 60" Gold: SchroderHaus – "Leveraging Social Media for Awareness and Engagement for Clipper Tea" Branded Content: Gold: BOK Financial – "Healthcare Cyberattacks White Paper" Feature Stories: Gold: Linhart Public Relations with Spire Midstream – "Contributed Content Highlights Need for Natural Gas Storage" Gold: CU Boulder Office of Strategic Relations & Communications – "How Animals Get their Stripes and Spots" Gold: Metropolitan State University of Denver – "Call Me Mister" Newsletters/Magazines: Gold: Metropolitan State University of Denver – "RED Newsfeed" Gold: Western Resource Advocates – "Field Notes" Best Use of Generative AI - Direct Audience Engagement: Gold: CIG Public Relations – "CDOT Impaired Driving Holiday Mug Shot Campaign" Data Insights: Gold: Hensel Phelps Marketing Communications Team & Swing Strategic Communication – "Hensel Phelps 2023 Communications Audit" Influencer Marketing: Gold: Linhart Public Relations with Chocolove – "Sweet Success: Activating Existing Brand Fans on Instagram by Showing the Chocolove" Gold: SchroderHaus – "Justin’s #JustinMyLunch Influencer Marketing" Gold: SchroderHaus – "Earth Month Goes Regenerative for Artisan Tropic" Videos: Silver: Metropolitan State University of Denver – "Art of Dueling" Websites: Gold: Western Resource Advocates – "A New Website for Western Resource Advocates’ Future" Podcasts: Silver: National Renewable Energy Laboratory – "NREL Reaches New Audiences with Launch of Science News Podcast" Media Relations: Gold: JKD & Company and The Church of Jesus Christ of Latter-day Saints – "11th Hour Push - Denver’s Giving Machines" Gold: Linhart Public Relations – "Beef. It’s What’s For Dinner. Combines Bench of Culinary Experts and Creative Media Strategy to Garner Year-Round National Media Coverage" Silver: CU Boulder Office of Strategic Relations & Communications – "Full Triceratops Skeleton Now Calls Boulder Home" Silver: SideCar Public Relations – "¡Viva! Streets Denver Drives Sustainability and Community Engagement Through Car-Free Streets" Silver: Barefoot PR – "Delta Dental of Colorado Foundation Invests in Oral Health Equity" Silver: Elasticity on behalf of Elevate Quantum – "A Mountain of Opportunity" Silver: Root Marketing & PR on behalf of Bubbies Fine Foods – "Making a Big Dill Out of Bubbies" Grand Gold Picks: The Grand Bold Pick is awarded to the "Best of Show" for the campaign with the highest overall score. This years, two organizations took home a Grand Gold Pick: Meadows PR and Visit Golden – "Goldens in Golden" National Disabled Veterans Winter Sports Clinic – "Miracles on a Mountainside" PRSA Colorado congratulates all winners for their exemplary work and contributions to the public relations industry in Colorado. The Public Relations Society of America ( www.prsa.org ) is the nation’s largest association for the professional practice of public relations. The Colorado Chapter ( www.prsacolorado.org ), headquartered in Westminster, is consistently one of the largest chapters in the country. The chapter provides timely and profession-specific educational programs, information and networking opportunities to all of its members, which include professionals at all levels working at corporations, local and national public relations agencies, government offices, universities, nonprofits and independent PR practitioners. Contact Details PRSA Colorado Chapter Alicia Nieva-Woodgate +1 415-515-0866 info@prsacolorado.org Company Website https://prsacolorado.org/

August 29, 2024 04:24 PM Eastern Daylight Time

Comcast Names Barry French Senior Vice President of External Affairs

Comcast Colorado

Comcast today announced that Barry French joined the company as Senior Vice President, External Affairs for Comcast’s West Division, based in Denver, Colo. An award-winning global marketing and communications executive and recognized government relations leader, French will drive the external affairs strategy for five regions and 13 states as the company expands its next-generation network. “Barry comes to Comcast with an excellent track record of achieving growth through brand awareness, government and regulatory affairs, and communications, said Rich Jennings, President, Comcast West Division. “His competitive nature and experience leading exceptional teams make him a great addition to our management team.” Having led engaged teams as large as 450 throughout 40 countries, French is known for driving change and delivering strong performance. His career has spanned industries, continents, and companies, including Dell, United Airlines, Nokia and the U.S. government. He most recently served as the Chief Marketing and Communications Officer at Inmarsat where he helped facilitate the successful $7.2 billion sale of the company to Viasat. As Chief Marketing and Communications Officer at Nokia, he significantly increased the value of its brand, repositioned the company, and added billions of dollars to the sales pipeline. Barry started his career in political consulting, working with clients in the United States and in more than a dozen other countries. A lifelong learner, French holds a Bachelor of Arts degree in Political Science from Bates College and a Master’s degree in International Affairs from Columbia University. He is an avid hiker and runner and lives with his wife and son in Boulder, Colo. About Comcast Corporation Comcast Corporation (Nasdaq: CMCSA) is a global media and technology company that connects people to moments that matter. We are principally focused on broadband, aggregation, and streaming with over 56 million customer relationships across the United States and Europe. We deliver broadband, wireless, and video through our Xfinity, Comcast Business, and Sky brands; create, distribute, and stream leading entertainment, sports, and news through Universal Filmed Entertainment Group, Universal Studio Group, Sky Studios, the NBC and Telemundo broadcast networks, multiple cable networks, Peacock, NBCUniversal News Group, NBC Sports, Sky News, and Sky Sports; and provide memorable experiences at Universal Parks and Resorts in the United States and Asia. Visit www.comcastcorporation.com for more information. Contact Details Comcast Leslie Oliver +1 303-810-6326 leslie_oliver@comcast.com Company Website https://colorado.comcast.com/

August 29, 2024 01:00 PM Eastern Daylight Time

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Nuvectis Pharma Rises in Pre-Market Following FDA Orphan Drug Designation for NXP800, Fueling Optimism Ahead of Key Clinical Data

Global Markets News

Nuvectis Pharma (NASDAQ: NVCT) has achieved a significant milestone with the U.S. Food and Drug Administration (FDA) granting Orphan Drug Designation for its lead candidate, NXP800. This designation, specifically for the treatment of ARID1a-deficient ovarian, fallopian tube, and primary peritoneal cancers, marks a critical step forward in Nuvectis’s mission to address unmet needs in oncology. Orphan Drug Designation: A Strategic Advantage The FDA’s Orphan Drug Designation is awarded to drugs that show promise in treating rare diseases affecting fewer than 200,000 people in the U.S. For Nuvectis, this designation not only validates the potential of NXP800 but also provides several strategic benefits. These include tax credits for clinical trial costs, exemption from certain FDA fees, and potentially seven years of market exclusivity upon approval. NXP800 targets ARID1a-deficient cancers, a subset of ovarian cancers that present significant treatment challenges. The Orphan Drug Designation underscores the importance of this candidate in potentially offering a new, more effective treatment option for patients with this specific genetic mutation. Background and Market Impact This latest achievement builds on Nuvectis Pharma’s earlier successes. Earlier this year, the FDA granted Fast Track Designation to NXP800 for its development in platinum-resistant, ARID1a-mutated ovarian cancer. The Fast Track status, combined with the Orphan Drug Designation, highlights the urgent need for innovative treatments in this space and positions NXP800 as a potential game-changer in oncology. Financial analysts have taken note of Nuvectis’s progress. H.C. Wainwright recently reiterated its buy rating for Nuvectis, setting a price target of $21. This optimistic outlook reflects the market’s confidence in the company’s strategic direction, particularly as it prepares to release key clinical data later this year. Anticipation for Upcoming Results The next few months are expected to be pivotal for Nuvectis Pharma. The company is poised to share updates from its ongoing Phase 1b clinical trial of NXP800, which targets patients with platinum-resistant, ARID1a-mutated ovarian cancer. This trial is being closely watched, as positive results could significantly advance the development of NXP800, bringing it closer to pivotal trials and eventual regulatory approval. Additionally, Nuvectis is also conducting a Phase 1a dose escalation study for NXP900, its second key candidate, which targets YES1/SRC-driven tumors. Updates from this study are expected to provide further insights into the safety and potential efficacy of NXP900. ### Nuvvectis' Full announcment, titled " Nuvectis Pharma Announces Orphan Drug Designation Granted by the FDA for NXP800 for the Treatment of ARID1a-deficient Ovarian, Fallopian Tube, and Primary Peritoneal Cancers" was published on August 29th, 2024. ### This article is for informational purposes only and is not intended to serve as financial, investment or any form of professional advice, recommendation or endorsement. Please review the full documentation detailing financial compensation disclosures and disclaimers the article is subject to. https://justpaste.it/fcm9n/pdf. Global Markets News Network is a commercial digital brand compensated to provide coverage of innovative companies and industries and it is thus subject to conflicts of interest. Contact Details Global Markets News News Coverage ronald@futuremarketsresearch.com

August 29, 2024 08:20 AM Eastern Daylight Time

How Seniors Can Benefit from Flip Phones

Spark Metro

In a world increasingly dominated by smartphones and constant connectivity, the simplicity of flip phones remains a compelling choice, particularly for seniors. While modern smartphones offer a multitude of features, their complexity can often be overwhelming for those who prioritize ease of use and straightforward functionality. For seniors, the balance between staying connected and maintaining simplicity is crucial, making flip phones an ideal solution. This article explores the many advantages of flip phones for seniors, highlighting how these devices offer a perfect blend of traditional simplicity and modern technology. The Appeal of Simplicity One of the most significant advantages of flip phones for seniors is their simplicity. Unlike smartphones, which require navigating complex menus and apps, flip phones offer a more straightforward interface. The act of flipping open the phone to answer a call and closing it to hang up is intuitive and familiar, providing a sense of nostalgia and comfort to many users. This simplicity reduces the learning curve, allowing seniors to use their phones confidently without needing extensive technical knowledge. Moreover, the tactile buttons on flip phones are often larger and more spaced out than those on smartphones, making them easier to press. This is particularly important for seniors who may struggle with dexterity or have vision impairments. The physical feedback of pressing a button, as opposed to the touchscreens of smartphones, adds to the ease of use, ensuring that seniors can make calls and send texts with minimal frustration. Enhanced Security and Privacy Another key advantage of flip phones for seniors is the enhanced security and privacy they offer. Smartphones are often vulnerable to various security threats, from phishing scams to malware, due to their internet connectivity and app usage. In contrast, flip phones have limited internet capabilities, significantly reducing the risk of cyber threats. For seniors who may not be as tech-savvy or aware of online risks, this limitation becomes a protective feature. Furthermore, flip phones typically do not store as much personal information as smartphones, which decreases the potential impact of losing the device. Seniors can feel more secure knowing that their personal data is less likely to be compromised if their phone is misplaced or stolen. This peace of mind is invaluable for those who prioritize security and privacy. Superior Battery Life Battery life is another area where flip phones excel, making them particularly well-suited for seniors. Smartphones are notorious for their relatively short battery life, often requiring daily charging due to their power-hungry apps and features. On the other hand, flip phones are designed with efficiency in mind, and their limited features contribute to significantly longer battery life. For seniors, the ability to go several days without needing to charge their phone is a major advantage. It reduces the hassle of constantly monitoring battery levels and ensures that their phone is always ready for use, particularly in emergencies. This reliability is a crucial factor for seniors who may not want to worry about their phone dying at an inconvenient time. Durability and Robust Design Flip phones are also known for their durability, a feature that is particularly important for seniors. The robust design of flip phones makes them less susceptible to damage from drops and other accidents, which are common concerns for users of all ages. The clamshell design not only protects the screen when the phone is closed but also adds a layer of protection against everyday wear and tear. This durability means that seniors can use their flip phones for extended periods without the need for frequent repairs or replacements. The sturdy construction of flip phones also makes them easier to handle, reducing the likelihood of accidental drops. For seniors, the combination of durability and ease of use ensures that their phone remains a reliable companion in their daily lives. Choosing the Right Flip Phone When selecting a flip phone for a senior, it's essential to consider specific features that cater to their needs. User-friendly features, reliable service, and a robust design are all critical factors to ensure that the phone meets their requirements. For instance, the Consumer Cellular IRIS Flip is an excellent option for seniors, offering a range of features designed with ease of use in mind. The large, easy-to-read display, intuitive navigation, and enhanced sound quality make it particularly suitable for those with vision or hearing impairments. Additionally, the IRIS Flip includes emergency response features, providing an added layer of security for seniors who may need assistance quickly. Its durable design ensures that it can withstand daily use, while the extended battery life means that seniors can rely on their phone to be ready when they need it most. The Importance of Reliable Service In addition to selecting a phone with the right features, it's also crucial to choose a provider that offers reliable service. For seniors, having a dependable network is essential for staying connected with family, friends, and emergency services. When considering a flip phone, ensure that the provider offers strong coverage in your area and has a reputation for excellent customer service. A good provider will also offer flexible plans that cater to the needs of seniors, such as low-cost options for those who primarily use their phone for calls and texts. This flexibility ensures that seniors are not paying for features they do not need, making their phone plan more affordable and tailored to their usage patterns. The Modern Benefits of a Traditional Design While flip phones may seem like a relic of the past, they continue to offer significant advantages in the digital age, especially for seniors. Their simplicity, enhanced security, superior battery life, and durability make them an attractive option for those who value straightforward, reliable communication. In addition to these benefits, modern flip phones have incorporated certain technological advancements that enhance their functionality without compromising their user-friendly design. Features such as voice commands, text-to-speech, and enhanced sound quality have been integrated into many flip phones, providing seniors with the convenience of modern technology while maintaining the simplicity they prefer. Conclusion For seniors, the choice of a mobile phone should prioritize ease of use, reliability, and security. Flip phones, with their intuitive design and practical features, offer a compelling solution that meets these needs. While smartphones dominate the market with their endless apps and features, the straightforward nature of flip phones provides a refreshing alternative, ensuring that seniors can stay connected without the complexity and distractions of more advanced devices. The Consumer Cellular IRIS Flip exemplifies the best of both worlds, combining the simplicity of a flip phone with carefully selected modern features that enhance usability and safety. By choosing the right flip phone, seniors can enjoy the benefits of staying connected while maintaining control over their digital experience. Contact Details Alex +1 302-597-6768 Apexreviews154@gmail.com

August 27, 2024 03:52 AM Eastern Daylight Time

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