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Market Alert: Buy Rating Reiterated for Actelis Networks with $5 Price Target

Actelis Networks, Inc.

Litchfield Hills Research analyst Theodore O'Neill has reiterated his Buy rating and $5 price target on Actelis Networks (Nasdaq: ASNS)* following the company's recent financial results. The analyst emphasizes that when viewed on a rolling four-quarter basis, Actelis' business is "moving in the right direction – up and to the right." The report highlights that Actelis shares are "priced significantly below peer averages," trading at a discount of 85% to 93% on sales measures compared to industry peers. O'Neill notes that if Actelis were to trade at the simple average of its peers at 3.67x 2026 Market cap/sales, the share price would exceed $6.00, above his current $5 target. For the full year 2024, Actelis reported revenue of ~$7.8 million, representing a 38% increase compared to FY2023. The company achieved a substantial improvement in gross margin to ~55% from ~34% in the prior year, demonstrating the effectiveness of its strategic shift toward IoT sales and higher-margin software components. Operating expenses decreased by ~13% year-over-year, reflecting the company's continued cost reduction initiatives while maintaining focus on its core markets including Federal, Military, and Smart City/Transportation sectors. Click here if you'd like to receive more alerts from us Recent Actelis Networks News Highlights: Actelis Networks to Report Annual 2024 Financial Results on Monday, March 24, 2025 Actelis Networks Reports Full Year 2024 Results: Revenue Sees 38% Growth Reaching $7.8 Million, 125% Increase in Gross Margin, Loss Per Share Shrinks by 67% to $0.85 Actelis Networks Secures Order for Countywide Intersection Modernization in Ventura County, California *DISCLAIMER: This alert is published by Wall Street Wire. Wall Street Wire does not provide financial or investment advice, and our content does not represent an offer to buy or sell securities. Wall Street Wire is a promotional content brand and its operators are not registered brokers, dealers, or investment advisers. This alert contains and is a form of paid promotional content for to Actelis Networks and was produced as part of their paid subscription to Wall Street Wire’s distribution and promotional content services. This alert has not been reviewed or approved by Actelis Networks prior to publication. Please review the full disclaimers and compensation disclosures here: redditwire.com/terms Contact Details WALL STREET WIRE Market Alerts Desk media.globalmarkets@gmail.com

March 27, 2025 12:33 PM Eastern Daylight Time

Monster Energy Continues the Launch of Java Monster Irish Crème Flavor In Spectacular Fashion at Chicago’s St. Patrick’s Day Celebrations

YourUpdateTV

In a city renowned for its spirited St. Patrick's Day celebration, Monster Energy is going all out to ensure the continued launch of Java Monster Irish Crème is as memorable as the legendary patron saint himself. The Chicago River will gleam a brilliant emerald green, mirroring the lively spirit of the day, thanks to Monster Energy's participation in the annual river-dyeing tradition. Monster Energy, the brand synonymous with exhilarating energy drinks, is continuing its innovation and celebration to the next level. In an unforgettable display of excitement and flavor, Monster Energy is proudly introducing its latest creation, the Java Monster Irish Crème, amidst the vibrant festivities of Chicago's St. Patrick's Day parade. The streets of Chicago will be alive with the roar of the Java Monster truck, a behemoth of energy making its way through the parade. Decked out in striking Monster Energy branding and the bold, irresistible allure of the Java Monster Irish Crème flavor, the truck will be a sight to behold. Adding to the day's excitement, the Monster Energy team, alongside the enchanting Monster Girls and a particularly mischievous leprechaun, will traverse the parade route. gifting thousands of eager parade-goers with cans of the Java Monster Irish Crème. This creamy, dreamy addition to the Java Monster lineup is infused with the rich, smooth taste of Irish crème, promising an invigorating energy boost with every sip. About Java Monster: No foam, extra hot, half-caf, no-whip, soy latte… enough of the coffeehouse BS already. It’s time to get out of the line and step up to what’s next. Java Monster, premium coffee and cream, brewed up with killer flavor, supercharged with the Monster Energy blend. Coffee done the monster way, wide open, with a take no prisoners attitude and the experience and know-how to back it up. Flavors include Mean Bean, Loca Moca, Salted Caramel, Irish Creme, Caffe Latte, and Triple Shot (Mocha and French Vanilla). So, shake gently and unleash the beast within. Java Monster – anything but basic! About Monster Energy: Based in Corona, California, Monster Energy is the leading marketer of energy drinks and alternative beverages. Refusing to acknowledge the traditional, Monster Energy supports the scene. Whether motocross, off-road, NASCAR, MMA, BMX, surf, snowboard, ski, skateboard, eSports or the rock and roll lifestyle, Monster Energy is a brand that believes in authenticity and the core of what its sports, athletes, gamers and musicians represent. More than a drink, it's the way of life lived by athletes, bands, believers, and fans. See more about Monster Energy including all of its drinks at www.monsterenergy.com. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

March 19, 2025 11:15 AM Eastern Daylight Time

Video

Market Alert: NeuroSense Therapeutics Advances Toward Early Canadian Commercialization of ALS Drug

Global Markets News

NeuroSense's Groundbreaking ALS Combination Therapy PrimeC Advances Towards commercialization in Canada potential for revenue in canada alone of $100-150 million dollars. PrimeC Has Previously Demonstrated Unprecedentedly Strong Clinical Efficacy; Market News Alerts Reports -- NeuroSense Therapeutics Ltd. (NASDAQ: NRSN)* has announced significant progress toward the early commercialization of PrimeC in Canada. According to a Form 6-K filed with the SEC this morning, Health Canada has invited the company to a pre-New Drug Submission (pre-NDS) meeting to discuss a potential Notice of Compliance/conditional (NOC/c) regulatory pathway for PrimeC as a treatment for Amyotrophic Lateral Sclerosis (ALS). NeuroSense is targeting potential approval in Canada by H1 2026. The company estimates peak annual revenue potential of $100-150M USD in the Canadian market. This meeting marks a critical step in NeuroSense's regulatory strategy for PrimeC PrimeC is NeuroSense's lead drug candidate for ALS, a novel extended-release oral formulation combining ciprofloxacin and celecoxib. The drug has demonstrated promising results in clinical trials, including the Phase 2b PARADIGM study, which showed a 36% reduction in disease progression and 43% improvement in survival rates compared to placebo. In December 2024, NeuroSense reported positive FDA feedback on its Phase 3 trial design for PrimeC, with plans to initiate the pivotal study in mid-2025. The company has also announced entering a binding term sheet with a global pharmaceutical company to advance PrimeC's development, which includes substantial upfront payments and funding for the Phase 3 program. This Canadian regulatory development represents a potential pathway to earlier commercialization while the larger Phase 3 program proceeds for global markets. The neurodegenerative disease treatment market has witnessed transformative licensing deals that highlight the immense value of innovative therapies. GlaxoSmithKline's 2021 collaboration with Alector set a remarkable precedent with a $700 million upfront payment and potential milestone payments of $1.5 billion, while the Biogen and Denali Therapeutics partnership in 2020 involved $560 million upfront and potential milestones approaching $1.125 billion. These deals underscore the pharmaceutical industry's willingness to invest heavily in breakthrough neurological innovations, potentially like NeuroSense's PrimeC. Some Wall Street Analysts reportedly maintain a Buy Rating for NeuroSense with AGP giving the company a $7.50 price target representing a significant premium over current Prices; * Disclaimer: Nothing in this report constitutes financial or investment advice, nor does it represent an offer to buy or sell securities. This alert is published by Market News Alerts, a promotional content brand which is part of the Wall Street Wire™ network. The operators of Wall Street Wire are not registered brokers, dealers, or investment advisers. This distribution is paid promotional content related to NeuroSense Therapeutics and was produced as part of their paid subscription to Wall Street Wire. This report has not been reviewed or approved by NeuroSense Therapeutics prior to publication. Please review the full disclaimers and compensation disclosures here: redditwire.com/terms. We are not responsible for the price targets mentioned in this article nor do we it endorse them, they are quoted based on publicly available news reports and additional or price targets may exist that may not have been quoted. Readers are advised to refer to the full reports mentioned on various systems and the disclaimers/disclosures they may be subject to. Contact Details Market News Alerts Editorial Desk globalmarkets.media@gmail.com

March 19, 2025 11:01 AM Eastern Daylight Time

Jeremiah Gregory Promoted to VP of Marketing Strategy at digifora

Digifora

On February 25th, digifora announced that Jeremiah Gregory had been made Vice President of Marketing Strategy. The promotion came on the heels of a strong and sustained performance, in which he helped guide many of digifora’s clients and partners to achieve and surpass many of their goals. The new position serves as an acknowledgment of past successes as well as a way to empower Gregory to continue his leadership role within the rapidly scaling full-service growth-marketing agency. Founder and president Justin Brackett emphasized that the move was meant as a genuine sign of gratitude and a thank you from the entire team at digifora, saying, “This is just as much a thank you for past efforts as a nod to future outcomes. It is a way for us to say ‘thank you’ for all the work he is doing and has done as we’ve grown.” Growth is an understatement. Digifora made waves in 2024 when it announced that it had hit its seven-year benchmarks in less than half that time. Since then, it has continued to build its team and suite of services into a combined offering that can address any marketing and communications concern for organizations in both for-profit and non-profit environments. Brackett pointed out that throughout that growth, Gregory has consistently shown up with a can-do attitude. “He is always willing to go above and beyond,” he said. “He embodies our flywheel of Trust & Education, leads with integrity, and always looks for ways to elevate our clients and team. His dedication and impact at digifora speak for themselves, and this promotion reflects the value he brings every day.” Jeremiah currently resides in Pfafftown, North Carolina, where he lives with his wife Erin and their three daughters. He previously served as Senior Director of Growth Marketing at digifora. Before that role, he had spent the better part of two decades accumulating expertise as an advertising, analytics, and digital marketing expert. During that time, he developed and executed omnichannel campaigns for major organizations including Media General, Hearst Television, Flow Automotive, and Reynolds American. Once at digifora, he served the agency’s clients in a variety of contexts and competencies. His main bread and butter has been media buying. He has leveraged this key marketing channel for clients through branded relationships including Disney, Mountain, Google, and Pandora, using it to serve a number of high-profile clients, including Arc of Indiana, Convey of Hope, and Vanderbloemen. In addition, Gregory has helped with platform development by making sure digifora maintains partnerships in the technology space that can help drive change for its clients. He has also helped develop dashboards, analytics, reporting, and any other data or communications-related needs to ensure clear and effective service. Gregory is particularly satisfied with his work alongside digifora’s non-profit partners. “I am thankful that I have been able to help multiple non-profits connecting people in need to valuable resources that provide hope,” he said, adding that one of those non-profits is the Villages in Indiana. “One of my favorite success metrics in recent years has been the simple yet powerful fact that we were able to help grow the number of parents registering to be foster parents year over year from 2023 to 2024.” It is this heart-felt love for the impact of his work, alongside his can-do attitude and nose for successful outcomes that has made Gregory a central and integral part of digifora’s success, and will doubtless keep him in that catalytic position moving forward. About digifora Digifora launched in 2020 with a vision to provide an elite, comprehensive suite of growth marketing services for clients across the United States in corporate, non-profit, and faith-based sectors. Its growing team provides end-to-end marketing and communications support, from strategy to implementation to follow-up across on-site, off-site, digital, and traditional channels. Learn more about our services at digifora.com. Contact Details digifora Jaron Pak +1 843-284-6594 digifora.co@gmail.com Company Website https://digifora.com

March 12, 2025 08:43 AM Eastern Daylight Time

NAVEX One: The Trusted Partner for NIS2 Risk Alignment

NAVEX Global

NAVEX, the global leader in integrated risk and compliance management software, is pleased to offer the first GRC solution to holistically address NIS2 across training, policies and assessment – all on one platform, NAVEX One. NAVEX continues to provide risk and compliance professionals with the tools they need to align with the latest cybersecurity regulations. As organizations face increasing regulatory demands, NAVEX One integrates policy management, training and risk assessment resources to ensure seamless compliance with the European Union’s Network and Information Security Directive (NIS2). The NIS2 Directive raises the bar for cybersecurity and reporting standards across industries, including banking, healthcare, manufacturing and energy. Organizations must not only comply with these heightened regulations but also ensure their cybersecurity frameworks are strong enough to withstand evolving threats. “NIS2 is a critical milestone in cybersecurity regulation, and organizations need a partner that helps them do more than just check the compliance box,” said A.G. Lambert, chief product officer at NAVEX. “NAVEX One empowers compliance and risk professionals to build a sustainable and proactive approach to cybersecurity, ensuring their programs are compliant and resilient against emerging threats.” NAVEX One serves as an essential tool in the journey toward risk and compliance maturity, helping organizations: Conduct proactive risk assessments to identify and mitigate vulnerabilities Centralize and streamline policy management to meet regulatory expectations Strengthen cybersecurity posture with comprehensive security awareness training Stay ahead of evolving cybersecurity requirements through continuous program improvement and board-ready reporting Extend training, policies and cyber risk practices to align third parties with its cyber risk standards “Organizations today require more than just static risk and compliance checklists—they need dynamic, integrated solutions that evolve with regulatory changes and emerging risks,” said Kyle Martin, vice president of risk solutions at NAVEX. “NAVEX One’s content and capabilities give businesses the confidence to proactively address NIS2 requirements while reinforcing their broader risk management strategies.” By integrating these capabilities within a single platform, NAVEX One simplifies compliance, reduces risk exposure, and supports organizations in building future-proof compliance programs. Click here, for more information on NAVEX One and the NIS2 Directive. NAVEX is trusted by thousands of customers worldwide to help them achieve the business outcomes that matter most. As the global leader in integrated risk and compliance management software and services, we deliver solutions through the NAVEX One platform, the industry’s most comprehensive governance, risk and compliance (GRC) information system. For more information, visit NAVEX.com and our blog. Follow us on Twitter and LinkedIn. Contact Details Navex Global scott.levesque@navex.com Company Website https://navex.com

February 18, 2025 12:50 PM Eastern Standard Time

Revenue Management Solutions and Norton Creative Partner Transform Restaurant Menus

Revenue Management Solutions

Hospitality experts Revenue Management Solutions (RMS) and Norton Creative are redefining menu strategy through a powerful partnership of experience, technology and know-how. Combining RMS’ menu analysis with remote eye-tracking technology and Norton’s menu design, the two industry leaders are helping restaurants optimize their menus for consumer engagement and profitability. RMS’ advanced eye-tracking software analyzes how consumers interact with digital menus, capturing gaze patterns and time spent on menu sections. Heat maps reveal what grabs potential diners’ attention. Norton Creative uses the information to design engaging menus that strategically showcase the most profitable items. With rapid testing available, menu information can be ready in as little as a week, ensuring maximum impact. “Restaurant brands need a menu that does more than list items — it has to guide the guest experience and influence purchasing behavior,” said RMS VP of Consulting for North America Justin Pridon. “With today’s consumers dining out less, an optimized menu can be the difference between lost sales and long-term loyalty.” According to a recent RMS survey, half of respondents dine out less frequently than before COVID-19. Additionally, younger generations and families have increased their reliance on digital ordering, underscoring the need for menus that function effectively across all platforms. “Restaurant brands are focused on how to get the most sales and profit out of their existing menu without changing customer favorites,” said Norton Creative Chief Client Officer Sara Harding Lou. “We use data to inform design that supports a restaurant company’s business objectives, whether it’s focused on improving margins, increasing profitability or bringing the brand promise to life.” Four leading restaurant brands are currently testing Norton and RMS-designed menus. The teams are onboarding many more, demonstrating how strategic menu evolution can boost profitability without relying solely on price increases. “With this data-driven approach, brands are seeing a real impact,” Pridon added. “By integrating technology with smart design, we’re helping restaurants turn their menus into powerful revenue drivers.” About Revenue Management Solutions For 30 years, Revenue Management Solutions (RMS) has partnered with restaurant brands to deliver actionable insights and data-driven solutions to boost sales, streamline costs and maximize profitability. Its AI-powered solutions support 150,000-plus locations worldwide, empowering brands to navigate challenges such as inflation and labor costs with confidence. Unlock the power of your data with RMS by visiting www.revenuemanage.com. About Norton Creative A Houston-based creative agency laser-focused on hospitality, Norton Creative gets global, national and local restaurant brands noticed. Thought leaders with decades of experience in launching and sustaining successful brands, Norton’s veteran team takes a strategic approach, with design expertise at every level of operations — from brand strategy to logo menus and packaging to signage and interiors to broadcast, print and digital ad campaigns. View their award-winning work at Norton Creative. Contact Details Center Reach Communications Tracy Henderson +1 720-989-3530 tracy@centerreachcommunication.com Company Website https://www.revenuemanage.com

February 13, 2025 09:15 AM Eastern Standard Time

Meet Perforator: the open-source tool that can save businesses billions a year in server costs, depending on company size

Yandex

Yandex, a global tech company, develops and open-sources Perforator, an innovative tool for continuous real-time monitoring and analysis of servers and applications. Perforator helps developers identify the most resource-intensive sections of code and provides detailed statistics for subsequent optimization. By identifying code inefficiencies and supporting profile-guided optimization, Perforator delivers accurate data that enables businesses to manually optimize their applications and reduce infrastructure costs by up to 20%. Depending on company size, this could translate to millions or even billions saved annually. “Perforator helps businesses get the most out of their servers without sacrificing performance," said Sergey Skvortsov, a senior developer at Yandex who leads the team behind the tool. "Using Perforator, businesses can optimize their code, reduce server load, and ultimately lower energy and equipment costs." Why use Perforator? Resource optimization is crucial for large data centers, big tech corporations, as well as small businesses and startups with limited resources. Instead of investing in additional equipment, companies can leverage Perforator to optimize their existing infrastructure without sacrificing performance. The tool has already been used for profiling in many Yandex services for over a year, and now it is accessible to companies, developers, and researchers worldwide. Companies can deploy Perforator on their own servers, minimizing reliance on external cloud providers while maintaining full control over their data. This makes Perforator a strong fit for organizations with stringent data security requirements operating within closed infrastructures. "Perforator can benefit companies of all sizes, from small businesses with 10-100 servers, which can save millions of dollars per year, to larger enterprises with thousands of servers and more, where savings can reach hundreds of millions or even billions of dollars annually, Sergey Skvortsov noted. “Regardless of your company size, Perforator can help you reduce infrastructure costs, freeing up resources for further innovation and growth.” How Perforator works Perforator provides detailed insights into server resource usage and analyzes the impact of code on performance, highlighting which applications consume the most system resources. Perforator uses eBPF technology to run small programs within the Linux kernel in a way that is safe and does not slow down the system. eBPF allows for improved monitoring, security, and performance optimization without changing the source code. Perforator supports native programming languages such as C, C++, Go, Rust, Python, and Java. The solution enables in-depth analytics and data visualization with flame graphs, making problem diagnostics much more manageable. “Perforator has been battle-tested in Yandex’s demanding environment for over a year and provides a wide range of features that make it a reliable and versatile solution for monitoring and optimizing server performance,” Sergey Skvortsov added. One of Perforator's key advantages is its support for profile-guided optimization (PGO), which automatically accelerates C++ programs by up to 10%. Additionally, Perforator is designed to run seamlessly on individual computers, making it accessible not only to large businesses but also to startups and tech enthusiasts. Furthermore, Perforator offers essential features tailored for large organizations, including A/B testing capabilities that help make better-informed decisions. Open-source solution for developers and businesses The decision to make Perforator open source reflects Yandex's commitment to fostering community collaboration in developing system technologies. “We believe that open-sourcing such fundamental system technologies helps drive tech innovation worldwide,” said Sergey Skvortsov. “We aim for our technologies to benefit the world and provide value to both developers and businesses. Additionally, the openness of the technology enables us to make decisions regarding the development of the profiling infrastructure together with the community.” What’s next? In the near future, Perforator will be enhanced with additional capabilities, including improved integration with Python and Java and more precise analysis of events. Perforator's source code is now available on GitHub, alongside other Yandex open-source solutions, such as YaFSDP, a tool designed to accelerate the training of large language models. Perforator is the latest addition to Yandex’s collection of open-source tools. You can view all of the company's open-source projects, including YaFSDP, AQLM, YTsaurus, and more, on this page. About Yandex Yandex is a global technology company that builds intelligent products and services powered by machine learning. Its goal is to help consumers and businesses better navigate the online and offline world. Since 1997, Yandex has delivered world-class, locally relevant search and information services and developed market-leading on-demand transportation services, navigation products, and other mobile applications for millions of consumers worldwide. Contact Details Media Team media@nettresults.com

January 30, 2025 08:59 AM Eastern Standard Time

3 Tokens Under $4, Ready To Hit $5 By March: Cardano (ADA), Ripple (XRP) And Cutoshi (CUTO)

Cutoshi

Following Donald Trump’s inauguration, the crypto market appears to be preparing for another rally. Thus, this article will uncover why Cardano (ADA), Ripple (XRP) and Cutoshi (CUTO) are the top three in our list of the altcoins positioned for the best surge in the following bull run and their potential returns. Cardano (ADA) Rises To Crucial Resistance, Will It Break Out? During the November 2024 rally, the ADA price surged remarkably, and Cardano gained over 300% within a month. Despite the momentum, ADA faced significant resistance from the $1.24 price level, which terminated the uptrend, and Cardano reversed, plunging over 30% in the next three weeks. Due to this decrease in demand, the price slowed down, and ADA traded sideways for over a month. Cardano has recovered significantly in the previous four days and has moved above the 50-day SMA. In the last 24 hours, ADA has surged by 7.43% and is trading at $1.12 but is facing rejection from the immediate resistance at $1.15, from where it has reversed multiple times. If ADA continues to gain demand, the price can move past this resistance level, and with sufficient momentum, Cardano can surpass the $1.24 resistance level to resume the rally. However, if the ADA price is rejected again, support levels exist at $1.05 and $1.02 to break the fall. Ripple (XRP) Continues Rally After Consolidation Ripple performed tremendously in the recent rally, with the price rising by over 400% after breaking from a critical resistance trendline. However, when the price reached $2.9, Ripple lost the upward thrust and started to trade in a symmetric triangle pattern. It continued to trade in this pattern for over a month and slowly consolidated into a tight range-bound price action. Ripple moved above the upper trendline of this triangle last week, has gained over 35% this week, and currently trades at $3.32. The price is only 14.39% below the ATH, which Ripple established over seven years ago, and is steadily rising. The MACD oscillator is rising fast, showing increasing bullish sentiment for Ripple. The price has become overbought due to increasing demand, as indicated by the Relative Strength Index (RSI) of 77.3. Ripple may reach a new ATH soon if this bullish pressure continues to push the price with similar momentum. Cutoshi (CUTO): Utility Meme Coin Set To Lead The 2025 Bull Market Cutoshi is a new hybrid project gaining popularity for its vision of transforming DeFi, using the power of memes and innovative platform features. It merges the fun of a meme community with the practicality of utility tokens to offer users a memeFi ecosystem that fulfills the requirements of all kinds of crypto investors. Cutoshi is reducing the DeFi knowledge gap to spread the mass adoption of DeFi and promote privacy, security and monetary freedom. It is building a learning academy to provide free learning materials for newcomers. These materials will break down complex Web3 concepts into easily understandable content to help users expand their knowledge and adapt to decentralized technologies. Moreover, Cutoshi is also bringing a merch shop into the ecosystem to offer community members a range of items including T-shirts, Hoodies, Phone cases, Mugs, etc. Members can receive special discounts on these items by using the native token CUTO to make payments on the platform. CUTO is available to acquire for $0.031 per token in the presale stage four and has already raised over $1,639,075.916 so far in the presale. The price will soon surge as the presale progresses to the next round, and new investors have an excellent opportunity to make similar returns through the compounding effect in further stages. For more information on the Cutoshi (CUTO) Presale: https://cutoshi.com/ Join and become a community member: https://twitter.com/CutoshiToken https://t.me/cutoshicommunity Cutoshi is a revolutionary meme coin inspired by the Chinese Lucky Cat and Satoshi Nakamoto’s teachings. It’s based on decentralization, privacy, and monetary freedom, embodying the blockchain's original purpose and ethos. Cutoshi has a vision to introduce more people to cryptocurrencies and bring financial freedom to all who want it. The regulatory environment surrounding cryptocurrencies is evolving and varies across jurisdictions. It is your responsibility to ensure compliance with applicable laws and regulations in your country or region before engaging with Custoshi. Contact Details Cutoshi Camila Perez support@cutoshi.com Company Website https://cutoshi.com/

January 29, 2025 04:50 PM Eastern Standard Time

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Market Alert: PESG Releases New Report Highlighting Silexion Therapeutics as an Emerging Leader in the Multi-Billion Dollar Precision Oncology Industry

Global Markets News

PESG Research releases new market update: Silexion Therapeutics (NASDAQ: SLXN) * continues to strengthen its position in the precision oncology landscape with breakthrough preclinical data validating systemic administration of SIL-204, potentially opening new frontiers in treating KRAS-driven cancers. This development comes amid increasing industry appetite for innovative oncology assets, exemplified by recent multi-billion dollar acquisitions. Silexion's latest preclinical findings mark a significant advancement in RNAi therapeutics, with data showing 50% tumor growth reduction and complete necrosis in half of treated tumors after 30 days, sustained therapeutic levels for over 56 days from a single administration, and broad coverage of key KRAS mutations (G12D, G12V, G12R, Q61H, and G13D). These results build upon previous successes, including promising synergy with first-line chemotherapies and the strategic collaboration with Evonik for advanced PLGA microparticle formulation. The precision oncology landscape has witnessed unprecedented consolidation, with Pfizer's $43 billion acquisition of Seagen and AbbVie's $10.1 billion purchase of Immunogen exemplifying the industry's willingness to invest heavily in innovative cancer therapeutics. These transactions reflect a broader industry shift toward precision medicine, particularly in oncology, where targeted therapies command significant premiums. Silexion's emergence as a potentially compelling player stems from its differentiated RNAi approach to targeting one of oncology's most challenging problems, offering broader applicability across multiple KRAS mutations compared to competitors' small molecule inhibitors. The first-generation LODER™ platform has already demonstrated promising Phase 2 results, while the next-generation SIL-204 advances toward clinical trials with successful validation of systemic administration. Notable industry analysts seem to have taken notice, with Maxim Group initiating coverage with a "strong buy" recommendation in November 2024 and an updated price target of $9. As Silexion advances toward clinical trials with SIL-204 and explores expanded development strategies, several key catalysts may lie ahead and could be worth watching closely, including metastasis impact studies, advancement towards next phases of trials, data from additional indications, potential strategic partnerships, and more positioning the company uniquely in the precision oncology landscape at a time when the industry actively seeks innovative solutions for challenging cancers. Click here to Subscribe for more updates like this Read out Previous update regarding Silexion Therapeutics Read out Previous update regarding Silexion Therapeutics >> We Encourage you to read the source news from Silexion: Silexion Therapeutics Reports Strong Tumor Growth Reduction from Systemic Administration of SIL-204 in Preclinical Pancreatic Cancer Models (*)Important Disclaimers & Disclosures: This report is for informational purposes only and should not be considered financial or investment advice. The author is not a registered financial or investment advisor nor does he hold any type of license or engage in any activity that would require one. The content may include forward-looking statements and opinions that may not materialize. Investors should conduct their own due diligence and consult with a qualified investment professional before making any investment decisions. This report was produced by ‘PESG Research’, a content brand which is part of the Wall Street Wire network, a digital coverage and news distribution subscription service and platform operated for commercial, promotional and investor relations purposes. This report contains advertising/promotional content relating to Silexion Therapeutics. Please review our detailed disclosure and disclaimer linked below which details the subscription fees the operators of PESG and the network of brands it is a part of received from Silexion Therapeutics and other customers for coverage, distribution and news promotion services, in accordance with Section 17(b) of the Securities Act. Please review the full disclaimers and disclosures this report is subject to: https://redditwire.com/terms. Contact Details Wall Street Wire Reports Desk* ronald@futuremarketsresearch.com

January 29, 2025 09:24 AM Eastern Standard Time

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